Asef, a link between the tumor suppressor APC and G-protein signaling - Test2 - elhamkhani - TriplyDB

Asef, a link between the tumor suppressor APC and G-protein signaling

Asef, a link between the tumor suppressor APC and G-protein signaling

http://www.wikidata.org/entity/Q24290104

about

RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1 Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability To build a synapse: signaling pathways in neuromuscular junction assembly Role of APC and DNA mismatch repair genes in the development of colorectal cancers.Global gene expression profiling of cells overexpressing SMC3.Examination of actin and microtubule dependent APC localisations in living mammalian cells.Regulation of small GTPases by GEFs, GAPs, and GDIs EB1 is required for spindle symmetry in mammalian mitosis Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells Tubulin tyrosination is required for the proper organization and pathfinding of the growth cone Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression Structure of the Human Discs Large 1 PDZ2– Adenomatous Polyposis Coli Cytoskeletal Polarity Complex: Insight into Peptide Engagement and PDZ Clustering A conformational switch in collybistin determines the differentiation of inhibitory postsynapses Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2 The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis The β-catenin destruction complex IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.Conserved microtubule-actin interactions in cell movement and morphogenesis RHO-GTPases and cancer Structural basis for the recognition of Asef by adenomatous polyposis coli.Autoinhibition of GEF activity in Intersectin 1 is mediated by the short SH3-DH domain linker.Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts.Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites.Molecular features of adult mouse small intestinal epithelial progenitors Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers.Novel association of APC with intermediate filaments identified using a new versatile APC antibody

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P2860

Asef, a link between the tumor suppressor APC and G-protein signaling

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2000 nî lūn-bûn

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2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2000 թվականի օգոստոսին հրատարակված գիտական հոդված

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2000年の論文

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Asef, a link between the tumor suppressor APC and G-protein signaling

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Asef, a link between the tumor suppressor APC and G-protein signaling

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Asef, a link between the tumor suppressor APC and G-protein signaling

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Asef, a link between the tumor suppressor APC and G-protein signaling

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Asef, a link between the tumor suppressor APC and G-protein signaling

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