Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? - Test2 - elhamkhani - TriplyDB

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

http://www.wikidata.org/entity/Q27690752

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ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2 Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases A landscape of driver mutations in melanoma Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment Neoadjuvant therapy for early-stage breast cancer: the clinical utility of pertuzumab The Significance of Ras Activity in Pancreatic Cancer Initiation Syndecans as Cell Surface Receptors in Cancer Biology. A Focus on their Interaction with PDZ Domain Proteins Regulation of small GTPases by GEFs, GAPs, and GDIs Molecular views of Arf-like small GTPases in cilia and ciliopathies Approaches of targeting Rho GTPases in cancer drug discovery Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channels Regulation of ROCK activity in cancer Molecular therapies in hepatocellular carcinoma: what can we target?Vav family exchange factors: an integrated regulatory and functional view The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange Targeting the RAS oncogene.Snf1/AMP-activated protein kinase activates Arf3p to promote invasive yeast growth via a non-canonical GEF domain.RAS isoforms and mutations in cancer at a glance Regulation and function of P-Rex family Rac-GEFs RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells DLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review)DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers A network-based classification model for deriving novel drug-disease associations and assessing their molecular actions A Pan-GTPase Inhibitor as a Molecular Probe Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics RhoGDI3 and RhoG: Vesicular trafficking and interactions with the Sec3 Exocyst subunit.The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration.Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion

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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

http://www.wikidata.org/entity/Q27690752

description

2010 nî lūn-bûn

@nan

2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

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2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

@ast

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

@en

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

@nl

type

label

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

@ast

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

@en

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

@nl

prefLabel

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

@ast

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

@en

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

@nl

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Nature Reviews Cancer

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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

@en

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Cherfils J

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Der CJ

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Rossman KL

http://www.w3.org/2001/XMLSchema#string

Vigil D

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A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway

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scholarly article

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1863361

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10.1038/NRC2960

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3124093

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