Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
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PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland developmentThe association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activityNetrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5BNeuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidaseHuman BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressorAkt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensationPhosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalingsGGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteinsPIKE-A is amplified in human cancers and prevents apoptosis by up-regulating AktThe centaurin gamma-1 GTPase-like domain functions as an NTPaseA novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine proteinPIKE GTPase signaling and functionNuclear PI3K signaling in cell growth and tumorigenesisThe roles of PIKE in tumorigenesisThe PIKE homolog Centaurin gamma regulates developmental timing in DrosophilaRBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancerNuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha)PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosisPhospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKEPIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasionThe LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs largeThe protein 4.1, ezrin, radixin, moesin (FERM) domain of Drosophila Coracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferationPIKE-mediated PI3-kinase activity is required for AMPA receptor surface expressionc-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBPPIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells.Substrate specificities and activities of AZAP family Arf GAPs in vivo.Phosphorylation of merlin regulates its stability and tumor suppressive activity.Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling.Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancerRe-examination of the mechanisms regulating nuclear inositol lipid metabolism.Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation.Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner.Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survivalSystematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations.A chemical biology approach identified PI3K as a potential therapeutic target for neurofibromatosis type 2Nuclear lipids: key signaling effectors in the nervous system and other tissues.GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortexEssential role of PIKE GTPases in neuronal protection against excitotoxic insults
P2860
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P2860
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
description
2000 nî lūn-bûn
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2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
@zh-hk
2000年論文
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2000年論文
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2000年论文
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name
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@ast
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@en
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@en-gb
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@nl
type
label
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@ast
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@en
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@en-gb
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@nl
prefLabel
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@ast
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@en
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@en-gb
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@nl
P2093
P1433
P1476
Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N
@en
P2093
C D Ferris
S Blackshaw
P304
P356
10.1016/S0092-8674(00)00195-1
P407
P577
2000-12-08T00:00:00Z