PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt - Test2 - elhamkhani - TriplyDB

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

http://www.wikidata.org/entity/Q24564005

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PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings The centaurin gamma-1 GTPase-like domain functions as an NTPase M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A PIKE GTPase signaling and function The roles of PIKE in tumorigenesis Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas CDK4is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells.Automated network analysis identifies core pathways in glioblastoma.Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship.Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner.Novel candidate key drivers in the integrative network of genes, microRNAs, methylations, and copy number variations in squamous cell lung carcinoma.Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.The role of semaphorins and their receptors in gliomas Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons.Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death.Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer?GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression.Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation.G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion.What we have learnt about PIKE from the knockout mice.Molecular heterogeneity of glioblastoma and its clinical relevance.Antiglioma effects of cytarabine on leptomeningeal metastasis of high-grade glioma by targeting the PI3K/Akt/mTOR pathway.Tumor Necrosis Factor-α Promotes Phosphoinositide 3-Kinase Enhancer A and AMP-Activated Protein Kinase Interaction to Suppress Lipid Oxidation in Skeletal Muscle.Arf proteins in cancer cell migration.Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity.Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling TMZ-BioShuttle--a reformulated temozolomide.Co-amplification of phosphoinositide 3-kinase enhancer A and cyclin-dependent kinase 4 triggers glioblastoma progression.α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.Akt2 and Akt3 play a pivotal role in malignant gliomas.Arf GAPs and molecular motors.

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P2860

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

http://www.wikidata.org/entity/Q24564005

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

@ast

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

@en

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

@nl

type

label

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

@ast

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

@en

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

@nl

prefLabel

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

@ast

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

@en

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

@nl

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PNAS.0400921101

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Proceedings of the National Academy of Sciences of the United States of America

P1476

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

@en

P2093

Jee-Yin Ahn

http://www.w3.org/2001/XMLSchema#string

Keqiang Ye

http://www.w3.org/2001/XMLSchema#string

Paulette Allard

http://www.w3.org/2001/XMLSchema#string

Todd G Kroll

http://www.w3.org/2001/XMLSchema#string

Yuanxin Hu

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Direct control of the Forkhead transcription factor AFX by protein kinase B

Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

Lamin proteolysis facilitates nuclear events during apoptosis

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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6993-8

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3694142

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10.1073/PNAS.0400921101

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18

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101

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8587391

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15118108

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P921

apoptotic process

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406454

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