Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins
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Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase CdeltaS6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cellsPKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase CzetaAcetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylationRegulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2Distinct protein kinase C isoforms mediate regulation of vascular endothelial growth factor expression by A2A adenosine receptor activation and phorbol esters in pheochromocytoma PC12 cellsPKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivityThe macrophage at the intersection of immunity and metabolism in obesityOxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways.Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activityPhosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.A novel clinically relevant animal model for studying galectin-3 and its ligands during colon carcinogenesisImproved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice.Intracellular signalling mechanisms regulating glucose transport in insulin-sensitive tissues (review).Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states.Computational modelling of the regulation of Insulin signalling by oxidative stress.Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases.Higher protein kinase C ζ in fatty rat liver and its effect on insulin actions in primary hepatocytesAcute Hepatic Insulin Resistance Contributes to Hyperglycemia in Rats Following Myocardial Infarction.Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistanceEffect of SNPs in protein kinase C zeta gene on gene expression in the reporter gene detection systemIgf2 ligand dependency of Pten(+/-) developmental and tumour phenotypes in the mouseMolecular approach to identify antidiabetic potential of Azadirachta indicaProtein kinase C/zeta (PRKCZ) gene is associated with type 2 diabetes in Han population of North China and analysis of its haplotypes.Role of chrysin on expression of insulin signaling molecules.Specific protein kinase C isoforms as transducers and modulators of insulin signalingTrauma and hemorrhage-induced acute hepatic insulin resistance: dominant role of tumor necrosis factor-alpha.Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.Regulating insulin signaling and beta-cell function through IRS proteins.Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes.Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only.Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases.Phosphorylation of IRS proteins, insulin action, and insulin resistance.Expression and function of the insulin receptor substrate proteins in cancerGlobal IRS-1 phosphorylation analysis in insulin resistance.Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes.
P2860
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P2860
Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@ast
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@en
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@en-gb
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@nl
type
label
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@ast
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@en
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@en-gb
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@nl
prefLabel
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@ast
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@en
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@en-gb
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@nl
P2093
P2860
P356
P1476
Insulin stimulates PKCzeta -me ...... e the function of IRS proteins
@en
P2093
A Herschkovitz
S R Sampson
T Tennenbaum
P2860
P304
P356
10.1074/JBC.M007281200
P407
P577
2001-04-27T00:00:00Z