S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
about
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolismAdipose tissue macrophages: going off track during obesityObesity and cancer, a case for insulin signalingInsulin receptor signaling in normal and insulin-resistant statesReviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose HomeostasisOver-nutrition and metabolic cardiomyopathyIs REDD1 a Metabolic Éminence Grise?Metformin and metabolic diseases: a focus on hepatic aspectsThe Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated ProteinsRegulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2Computer-aided targeting of the PI3K/Akt/mTOR pathway: toxicity reduction and therapeutic opportunitiesS6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancerPhosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinaseRegulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese miceIdentification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretionSerine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cellsTBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activityRapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardiumInhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol.Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling.Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.Dominant negative inhibition data should be analyzed using mathematical modeling--re-interpreting data from insulin signaling.Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation.Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditureE2F1 regulates cellular growth by mTORC1 signaling.Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms.Adenovirus infection results in alterations of insulin signaling and glucose homeostasis.Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy.Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes.Mechanisms of insulin resistance in obesityS6 kinase 2 promotes breast cancer cell survival via Akt.Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.Strain-dependent differences for suppression of insulin-stimulated glucose uptake in skeletal and cardiac muscle by ethanol.Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells.The Impact of Overnutrition on Insulin Metabolic Signaling in the Heart and the KidneyNovel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null micePlasma Proteomic Signature in Overweight Girls Closely Correlates with Homeostasis Model Assessment (HOMA), an Objective Measure of Insulin Resistance.Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation.Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance
P2860
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P2860
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@ast
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@en
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@en-gb
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@nl
type
label
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@ast
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@en
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@en-gb
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@nl
prefLabel
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@ast
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@en
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@en-gb
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@nl
P2093
P2860
P921
P3181
P356
P1476
S6K directly phosphorylates IR ...... (alpha) signaling through IKK2
@en
P2093
P2860
P304
35375-35382
P3181
P356
10.1074/JBC.M806480200
P407
P577
2008-10-24T00:00:00Z