Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism
about
Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexesAPE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactionsInhibition of Ape1 nuclease activity by lead, iron, and cadmium.Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis riskEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleEvolution of the redox function in mammalian apurinic/apyrimidinic endonucleaseStructure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamilyNMR Solution Structures of Clustered Abasic Site Lesions in DNA: Structural Differences between 3′-Staggered (−3) and 5′-Staggered (+3) Bistranded LesionsPb 2+ as Modulator of Protein–Membrane InteractionsStructural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidisConserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair EnzymesStructure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+cofactorSaccharomyces cerevisiae Ngl3p is an active 3'-5' exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases.Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activityEndoribonucleases--enzymes gaining spotlight in mRNA metabolism.Effects of mono- and divalent metal ions on DNA binding and catalysis of human apurinic/apyrimidinic endonuclease 1.Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1.New insights in the removal of the hydantoins, oxidation product of pyrimidines, via the base excision and nucleotide incision repair pathways.Taking U out, with two nucleases?Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1.Redox regulation of DNA repair: implications for human health and cancer therapeutic development.Lys98 substitution in human AP endonuclease 1 affects the kinetic mechanism of enzyme action in base excision and nucleotide incision repair pathways.Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ-C.High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.Endonuclease IV Is the major apurinic/apyrimidinic endonuclease in Mycobacterium tuberculosis and is important for protection against oxidative damageCloning and characterization of a wheat homologue of apurinic/apyrimidinic endonuclease Ape1LCharacterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease.APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Capturing snapshots of APE1 processing DNA damage.Defining the functional footprint for recognition and repair of deaminated DNAMolecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm.Characterization of Mg2+ binding to the DNA repair protein apurinic/apyrimidic endonuclease 1 via solid-state 25Mg NMR spectroscopy.Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.Going ape as an approach to cancer therapeutics.Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate.Comparative analysis of editosome proteins in trypanosomatidsCoordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements.
P2860
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P2860
Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Two divalent metal ions in the ...... ns for the catalytic mechanism
@ast
Two divalent metal ions in the ...... ns for the catalytic mechanism
@en
Two divalent metal ions in the ...... ns for the catalytic mechanism
@en-gb
Two divalent metal ions in the ...... ns for the catalytic mechanism
@nl
type
label
Two divalent metal ions in the ...... ns for the catalytic mechanism
@ast
Two divalent metal ions in the ...... ns for the catalytic mechanism
@en
Two divalent metal ions in the ...... ns for the catalytic mechanism
@en-gb
Two divalent metal ions in the ...... ns for the catalytic mechanism
@nl
prefLabel
Two divalent metal ions in the ...... ns for the catalytic mechanism
@ast
Two divalent metal ions in the ...... ns for the catalytic mechanism
@en
Two divalent metal ions in the ...... ns for the catalytic mechanism
@en-gb
Two divalent metal ions in the ...... ns for the catalytic mechanism
@nl
P2093
P356
P1476
Two divalent metal ions in the ...... ns for the catalytic mechanism
@en
P2093
Beernink PT
Erzberger JP
Segelke BW
Wilson DM 3rd
P304
P356
10.1006/JMBI.2001.4529
P407
P577
2001-04-01T00:00:00Z