Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation - Test2 - elhamkhani - TriplyDB

Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation

Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation

http://www.wikidata.org/entity/Q24291128

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The generation and function of soluble apoE receptors in the CNS Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits Association of apolipoprotein J-positive beta-amyloid plaques with dystrophic neurites in Alzheimer's disease brain Impact of apolipoprotein E on Alzheimer's disease Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's disease Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain Enrichment of cholesterol in microdissected Alzheimer's disease senile plaques as assessed by mass spectrometry.Nuclear uptake of an amino-terminal fragment of apolipoprotein E4 promotes cell death and localizes within microglia of the Alzheimer's disease brain.An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42 Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity A distinct subfraction of Aβ is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brain Apolipoprotein E: from lipid transport to neurobiology Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.Mass spectrometry quantification revealed accumulation of C-terminal fragment of apolipoprotein E in the Alzheimer's frontal cortex.Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal protease Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines.Sporadic cerebral amyloid angiopathy: pathology, clinical implications, and possible pathomechanisms.Apolipoprotein E and cholesterol in aging and disease in the brain The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific.Apolipoproteins and amyloid fibril formation in atherosclerosis.Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights Preparation, characterization and in vitro-targeted delivery of novel Apolipoprotein E-based nanoparticles to C6 glioma with controlled size and loading efficiency.A 13 kDa carboxy-terminal fragment of ApoE stabilizes Abeta hexamers.Full-length apolipoprotein E protects against the neurotoxicity of an apoE-related peptide F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein.IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons.Sporadic cerebral amyloid angiopathy is not a frequent cause of spontaneous brain hemorrhage.Clinical manifestations of cerebral amyloid angiopathy-related inflammation.Nuclear Localization of Apolipoprotein E4: A New Trick for an Old Protein.Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.The serine protease HtrA1 contributes to the formation of an extracellular 25-kDa apolipoprotein E fragment that stimulates neuritogenesis.Evaluation of Apolipoprotein E Fragmentation as a Biomarker for Alzheimer's Disease.Unexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy: an autopsy study.

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Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation

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Quantitation of apoE domains i ...... for apoE in Abeta aggregation

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B T Hyman

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P2860

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Apolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Lipoprotein receptors: signaling functions in the brain?

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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Alzheimer's disease

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