Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit
about
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicasesATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorTelomere shortening in human diseasesMRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length controlThe involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeresInteraction of FANCD2 and NBS1 in the DNA damage responseThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlFission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repairc-Myc directly regulates the transcription of the NBS1 gene involved in DNA double-strand break repairTelomeres and human disease: ageing, cancer and beyondGenetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma.The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.Telomeres: protecting chromosomes against genome instabilityTelomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70.The MRN complex in double-strand break repair and telomere maintenance.Mechanisms of double-strand break repair in somatic mammalian cells.NBS1 plays a synergistic role with telomerase in the maintenance of telomeres in Arabidopsis thaliana.Genetic Variations in Telomere Maintenance, with Implications on Tissue Renewal Capacity and Chronic Disease Pathologies.Telomeres, chromosome instability and cancerDisruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBN(p70) protein undergo p38/MK2-dependent premature senescence.Need telomere maintenance? Call 911Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging.Telomerase prevents accelerated senescence in glucose-6-phosphate dehydrogenase (G6PD)-deficient human fibroblasts.The mre11 complex and the response to dysfunctional telomeres.Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation.Taming the tiger by the tail: modulation of DNA damage responses by telomeres.ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance.Uncoupling of telomere length and radiosensitivity in mouse lymphoma cell lines of similar genetic background.The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1.Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2Radiation-induced telomere length variations in normal and in Nijmegen Breakage Syndrome cells.Telomerase activity is required for the telomere G-overhang structure in Trypanosoma brucei.Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.Identification of variants in pleiotropic genes causing "isolated" premature ovarian insufficiency: implications for medical practice
P2860
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P2860
Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Rescue of a telomere length de ...... d telomerase catalytic subunit
@ast
Rescue of a telomere length de ...... d telomerase catalytic subunit
@en
Rescue of a telomere length de ...... d telomerase catalytic subunit
@en-gb
Rescue of a telomere length de ...... d telomerase catalytic subunit
@nl
type
label
Rescue of a telomere length de ...... d telomerase catalytic subunit
@ast
Rescue of a telomere length de ...... d telomerase catalytic subunit
@en
Rescue of a telomere length de ...... d telomerase catalytic subunit
@en-gb
Rescue of a telomere length de ...... d telomerase catalytic subunit
@nl
prefLabel
Rescue of a telomere length de ...... d telomerase catalytic subunit
@ast
Rescue of a telomere length de ...... d telomerase catalytic subunit
@en
Rescue of a telomere length de ...... d telomerase catalytic subunit
@en-gb
Rescue of a telomere length de ...... d telomerase catalytic subunit
@nl
P2093
P921
P1433
P1476
Rescue of a telomere length de ...... d telomerase catalytic subunit
@en
P2093
D M Livingston
D N Ciccone
D T Weaver
E Seemanova
R A DePinho
P304
P356
10.1016/S0960-9822(01)00267-6
P407
P577
2001-06-01T00:00:00Z