Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence - Test2 - elhamkhani - TriplyDB

Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence

Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence

http://www.wikidata.org/entity/Q24292295

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IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system.The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.Mutation and evolutionary analyses identify NR2E1-candidate-regulatory mutations in humans with severe cortical malformations Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3 The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation.Sequence conservation and combinatorial complexity of Drosophila neural precursor cell enhancers.INSM1 promoter-driven adenoviral herpes simplex virus thymidine kinase cancer gene therapy for the treatment of primitive neuroectodermal tumors Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation.EVOPRINTER, a multigenomic comparative tool for rapid identification of functionally important DNA Xenopus insm1 is essential for gastrointestinal and pancreatic endocrine cell development.Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0.Functional role of an islet transcription factor, INSM1/IA-1, on pancreatic acinar cell trans-differentiation Neurogenin 3 recruits CBP co-activator to facilitate histone H3/H4 acetylation in the target gene INSM1.Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function Insm1 promotes neurogenic proliferation in delaminated otic progenitors An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma The growth factor independence-1 transcription factor: new functions and new insights.Snail/Gfi-1 (SNAG) family zinc finger proteins in transcription regulation, chromatin dynamics, cell signaling, development, and disease On the origin of the beta cell.Extra-nuclear activity of INSM1 transcription factor enhances insulin receptor signaling pathway and Nkx6.1 expression through RACK1 interaction.REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain.Insm1a Is Required for Zebrafish Posterior Lateral Line Development.Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro.Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing and neuronogenic.Insulinoma-associated 1: A novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma).Solution NMR structure of zinc finger 4 and 5 from human INSM1, an essential regulator of neuroendocrine differentiation.Structural Insights into c-Myc-interacting Zinc Finger Protein-1 (Miz-1) Delineate Domains Required for DNA Scanning and Sequence-specific Binding.A transcription factor collective defines the HSN serotonergic neuron regulatory landscape.INSM1 Expression Is Frequent in Primary Central Nervous System Neoplasms but Not in the Adult Brain Parenchyma.

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Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence

http://www.wikidata.org/entity/Q24292295

description

2002 nî lūn-bûn

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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2002 թվականի փետրվարին հրատարակված գիտական հոդված

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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name

Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

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Nucleic Acids Research

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Neuroendocrine differentiation ...... onsensus IA-1 binding sequence

@en

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Abner L Notkins

http://www.w3.org/2001/XMLSchema#string

Mary B Breslin

http://www.w3.org/2001/XMLSchema#string

Michael S Lan

http://www.w3.org/2001/XMLSchema#string

Min Zhu

http://www.w3.org/2001/XMLSchema#string

P2860

The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation.

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9

Control of endodermal endocrine development by Hes-1

The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc finger transcription factor

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1038-1045

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scholarly article

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10.1093/NAR/30.4.1038

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P433

4

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30

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2002-02-01T00:00:00Z

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11519185

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P698

11842116

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DNA-binding transcription factor activity

INSM transcriptional repressor 1

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100352

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