Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein - Test2 - elhamkhani - TriplyDB

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

http://www.wikidata.org/entity/Q24292430

about

Modeling of a human circadian mutation yields insights into clock regulation by PER2 PML regulates PER2 nuclear localization and circadian function Biochemical analysis of the canonical model for the mammalian circadian clock Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS)A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity A role for cryptochromes in sleep regulation Development of transgenic minipigs with expression of antimorphic human cryptochrome 1 The Potorous CPD photolyase rescues a cryptochrome-deficient mammalian circadian clock Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2 SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket Coordination of circadian timing in mammals Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts.A "Timed" Kiss Is Essential for Reproduction: Lessons from Mammalian Studies Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock Emerging models for the molecular basis of mammalian circadian timing Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock Reversible protein phosphorylation regulates circadian rhythms Metabolism as an integral cog in the mammalian circadian clockwork Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2.A clockwork web: circadian timing in brain and periphery, in health and disease Mammalian circadian biology: elucidating genome-wide levels of temporal organization CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1 Generation of a novel allelic series of cryptochrome mutants via mutagenesis reveals residues involved in protein-protein interaction and CRY2-specific repression.Structure/function analysis of Xenopus cryptochromes 1 and 2 reveals differential nuclear localization mechanisms and functional domains important for interaction with and repression of CLOCK-BMAL1 Day-night expression patterns of clock genes in the human pineal gland.Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation.MicroRNAs shape circadian hepatic gene expression on a transcriptome-wide scale.Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.Circadian phase-specific degradation of the F-box protein ZTL is mediated by the proteasome Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.

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P2860

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

http://www.wikidata.org/entity/Q24292430

description

2002 nî lūn-bûn

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2002 թուականի Մարտին հրատարակուած գիտական յօդուած

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2002 թվականի մարտին հրատարակված գիտական հոդված

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The EMBO Journal

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Nucleocytoplasmic shuttling an ...... ion of the mPER2 clock protein

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Filippo Tamanini

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Hitoshi Okamura

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Jan H J Hoeijmakers

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Kazuhiro Yagita

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Maya Yasuda

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P2860

Nuclear entry mechanism of rat PER2 (rPER2): role of rPER2 in nuclear localization of CRY protein

Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2

CRM1 is an export receptor for leucine-rich nuclear export signals

Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.

Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon.

Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.

Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.

Role of the CLOCK protein in the mammalian circadian mechanism

Nucleocytoplasmic transport: the soluble phase

Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

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1301-1314

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3786605

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10.1093/EMBOJ/21.6.1301

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6

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21

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Gijsbertus van der Horst

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2002-03-01T00:00:00Z

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11474328

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11889036

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Cryptochrome 1 (photolyase-like)

Period circadian clock 2

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125916

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