Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation
about
Human perforin employs different avenues to damage membranesN-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathwaySerglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storageLactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector FunctionsPerforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosisImaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion.The immune synapse clears and excludes molecules above a size threshold.Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin.Analysis of a set of Australian northern brown bandicoot expressed sequence tags with comparison to the genome sequence of the South American grey short tailed opossum.Perforin enhances the granulysin-induced lysis of Listeria innocua in human dendritic cells.Serglycin in human cancersCationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.Perforin rapidly induces plasma membrane phospholipid flip-flopPerforin: more than just a pore-forming protein.Perforin: structure, function, and role in human immunopathology.Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.Reciprocal complementation of the tumoricidal effects of radiation and natural killer cellsSingle-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice.Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.Extensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome.Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption.Perforin activity at membranes leads to invaginations and vesicle formation.Intracellular proteoglycans.Absence of perforin expression confers axonal protection despite demyelination.Serglycin in Quiescent and Proliferating Primary Endothelial Cells.Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida ΔfopC vaccine strain.Perforin and lymphohistiocytic proliferative disorders.Impaired T-bet-pSTAT1α and perforin-mediated immune responses in the tumoral region of lung adenocarcinoma.Liver immunobiology.Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation.The proteoglycan repertoire of lymphoid cellsPerforin and Fas/FasL cytolytic pathways at the maternal-fetal interface.Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.Human NK cell lytic granules and regulation of their exocytosisSerglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice.T-cell immunity generated by recombinant adenovirus vaccines.Mechanisms of granule-dependent killing.Dendritic cells are required for optimal activation of natural killer functions following primary infection with herpes simplex virus type 1.Serglycin: at the crossroad of inflammation and malignancy.
P2860
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P2860
Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@ast
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@en
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@en-gb
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@nl
type
label
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@ast
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@en
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@en-gb
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@nl
prefLabel
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@ast
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@en
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@en-gb
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@nl
P2093
P921
P1433
P1476
Cytotoxic cell granule-mediate ...... plasma membrane pore formation
@en
P2093
Baikun Wang
Christopher J Froelich
Eckhard Podack
Joseph A Trapani
Lars Uhlin-Hansen
Miguel Aguilar-Santelises
Srikumar M Raja
Sunil S Metkar
P304
P356
10.1016/S1074-7613(02)00286-8
P407
P577
2002-03-01T00:00:00Z