Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
about
Neuropilin-2 expression in breast cancer: correlation with lymph node metastasis, poor prognosis, and regulation of CXCR4 expressionMethodology for Anti-Gene Anti-IGF-I Therapy of Malignant TumoursNeuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesisThe cytoplasmic domain of neuropilin-1 regulates focal adhesion turnoverNeuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cellsGuidance molecules in lung cancerTargeting neuropilin-1 in human leukemia and lymphomaSmall molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interactionNeuropilin-1 identifies endothelial precursors in human and murine embryonic stem cells before CD34 expressionNeuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivityVEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesisNRP1 function and targeting in neurovascular development and eye diseasePharmacologic resistance in colorectal cancer: a reviewLymphangiogenesis and metastasis--a closer look at the neuropilin/semaphorin3 axisRecent applications of chemosensitivity tests for colorectal cancer treatmentNeuropilins: expression and roles in the epitheliumExtracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning.Receptor tyrosine kinase-mediated angiogenesisMolecular control of endothelial cell behaviour during blood vessel morphogenesisBevacizumab treatment for advanced breast cancerSemaphorin 3A suppresses tumor growth and metastasis in mice melanoma modelStructural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF bindingAngiogenesis and liver fibrosisVEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylationTie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defectsWnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesisHeparan sulfate signaling in cancerNeuropilin-2 mediated β-catenin signaling and survival in human gastro-intestinal cancer cell linesTumor angiogenesisA graph theoretic approach to utilizing protein structure to identify non-random somatic mutations.Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors.Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironmentNormalization of the vasculature for treatment of cancer and other diseases.Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells.Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cellsVEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancerNeuropilin-1 modulates p53/caspases axis to promote endothelial cell survival.Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cellsA phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors.A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors.
P2860
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P2860
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@ast
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@en
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@en-gb
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@nl
type
label
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@ast
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@en
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@en-gb
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@nl
prefLabel
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@ast
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@en
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@en-gb
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@nl
P2093
P3181
P1433
P1476
Blocking neuropilin-1 function ...... i-VEGF to inhibit tumor growth
@en
P2093
Alexander W Koch
Anil Bagri
Franklin Peale
Glenn Pacheco
Greg Plowman
Jennifer Le Couter
Joe Kowalski
Nisha Rathore
P3181
P356
10.1016/J.CCR.2006.10.018
P407
P577
2007-01-01T00:00:00Z