Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments
about
Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer developmentUsp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis.Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cellsThe chromosomal passenger complex activates Polo kinase at centromeresATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagyCK2 phosphorylation of human centrins 1 and 2 regulates their binding to the DNA repair protein XPC, the centrosomal protein Sfi1 and the phototransduction protein transducin βRegulatory functional territory of PLK-1 and their substrates beyond mitosis.Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer TreatmentPolo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication.Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.Hypoxia promotes satellite cell self-renewal and enhances the efficiency of myoblast transplantationCotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate CancerCdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachmentsA stringent requirement for Plk1 T210 phosphorylation during K-fiber assembly and chromosome congressionMaking an effective switch at the kinetochore by phosphorylation and dephosphorylation.The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores.The sequential activation of the mitotic microtubule assembly pathways favors bipolar spindle formationCasein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos.Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells.The substrates of Plk1, beyond the functions in mitosis.Regulatory mechanisms of kinetochore-microtubule interaction in mitosis.Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles.Linked in: formation and regulation of microtubule attachments during chromosome segregation.Polo-like kinases: structural variations lead to multiple functions.Unconventional Functions of Mitotic Kinases in Kidney Tumorigenesis.Low-dose arsenic-mediated metabolic shift is associated with activation of Polo-like kinase 1 (Plk1).Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics.Plk1 inhibition enhances the efficacy of androgen signaling blockade in castration-resistant prostate cancer.Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.Plk1-dependent microtubule dynamics promotes androgen receptor signaling in prostate cancerKindlin1 regulates microtubule function to ensure normal mitosisPhosphorylation of PP1 Regulator Sds22 by PLK1 Ensures Accurate Chromosome Segregation.Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein.Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration.Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics.Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.Co-expressions of casein kinase 2 (CK2) subunits restore the down-regulation of tubulin levels and disruption of microtubule structures caused by PrP mutants.Two-step interphase microtubule disassembly aids spindle morphogenesis.Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.
P2860
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P2860
Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments
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2010 nî lūn-bûn
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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
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Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
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Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
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Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
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label
Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
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Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
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Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
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Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
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prefLabel
Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
@ast
Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
@en
Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
@en-gb
Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
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Phosphorylation of CLIP-170 by ...... ochore-microtubule attachments
@en
P2093
Hongchang Li
Jerrold R Turner
X Shawn Liu
Xiaoming Yang
Xiaoqi Liu
Yingmin Wang
P2860
P304
P3181
P356
10.1038/EMBOJ.2010.174
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P577
2010-07-27T00:00:00Z