Making an effective switch at the kinetochore by phosphorylation and dephosphorylation. - Test2 - elhamkhani - TriplyDB

Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.

Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.

http://www.wikidata.org/entity/Q36879638

about

The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling A role of WT1 in cell division and genomic stability Epigenetic Histone Marks of Extended Meta-Polycentric Centromeres of Lathyrus and Pisum Chromosomes Kinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells Bod1 regulates protein phosphatase 2A at mitotic kinetochores Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores Control of the spindle checkpoint by lateral kinetochore attachment and limited Mad1 recruitment.Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules.Nuclear assembly shaped by microtubule dynamics.Tension-dependent removal of pericentromeric shugoshin is an indicator of sister chromosome biorientation.The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling.The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis.Structure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control.Partial Hepatectomy in Acetylation-Deficient BubR1 Mice Corroborates that Chromosome Missegregation Initiates Tumorigenesis.Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancer Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests A quantitative description of Ndc80 complex linkage to human kinetochores A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.Bistability of a coupled Aurora B kinase-phosphatase system in cell division.Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization HP1-Assisted Aurora B Kinase Activity Prevents Chromosome Segregation Errors The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.Autoinhibition and Polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase Haspin to mitosis.The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse Oocytes "Uno, nessuno e centomila": the different faces of the budding yeast kinetochore.Signalling dynamics in the spindle checkpoint response.Shugoshins: tension-sensitive pericentromeric adaptors safeguarding chromosome segregation GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics.PP2A-B56γ is required for an efficient spindle assembly checkpoint.Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation.

P2860

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P2860

Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.

http://www.wikidata.org/entity/Q36879638

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

@yue

2013年論文

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2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.

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type

label

Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.

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prefLabel

Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.

@en

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Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.

@en

P2093

David J Wynne

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Hironori Funabiki

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes

Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1

Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments

Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores

Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.

The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction.

Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1

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s00412-013-0401-5

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135-158

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10.1007/S00412-013-0401-5

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3

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122

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phosphorylation

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3665160

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