Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation
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A PACS-1, GGA3 and CK2 complex regulates CI-MPR traffickingThe human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-terminiPRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradationAn interaction between human Sec63 and nucleoredoxin may provide the missing link between the SEC63 gene and polycystic liver diseaseInternational Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyMechanisms of nephronophthisis and related ciliopathiesMitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytesThe functions of TRPP2 in the vascular systemA polycystin-centric view of cyst formation and disease: the polycystins revisitedAlternative splicing-mediated targeting of the Arabidopsis GLUTAMATE RECEPTOR3.5 to mitochondria affects organelle morphologyDrosophila sperm swim backwards in the female reproductive tract and are activated via TRPP2 ion channelsSitus inversus in Dpcd/Poll-/-, Nme7-/- , and Pkd1l1-/- micePACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicityProtein interactions of the vesicular glutamate transporter VGLUT1Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel FunctionTRP channelsFunction and dynamics of PKD2 in Chlamydomonas reinhardtii flagella.A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.The role for HNF-1beta-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells.N-glycosylation determines the abundance of the transient receptor potential channel TRPP2Molecular advances in autosomal dominant polycystic kidney disease.PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis.Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.The cell biology of polycystic kidney diseaseProtein phosphatase-1α interacts with and dephosphorylates polycystin-1Protein kinase D-mediated phosphorylation of polycystin-2 (TRPP2) is essential for its effects on cell growth and calcium channel activity.Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia.Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanismCasein kinase II and calcineurin modulate TRPP function and ciliary localizationIntracellular calcium release modulates polycystin-2 trafficking.The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest.The versatile nature of the calcium-permeable cation channel TRPP2Identification of a pH sensor in the furin propeptide that regulates enzyme activationA homeostatic switch in PACS-2 links membrane traffic to TRAIL-induced apoptosis.At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.
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P248
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P2860
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation
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2005 nî lūn-bûn
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2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2005 թվականի փետրվարին հրատարակված գիտական հոդված
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2005年の論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年论文
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Trafficking of TRPP2 by PACS p ...... nism of ion channel regulation
@ast
Trafficking of TRPP2 by PACS p ...... nism of ion channel regulation
@en
Trafficking of TRPP2 by PACS p ...... nism of ion channel regulation
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type
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Trafficking of TRPP2 by PACS p ...... nism of ion channel regulation
@ast
Trafficking of TRPP2 by PACS p ...... nism of ion channel regulation
@en
Trafficking of TRPP2 by PACS p ...... nism of ion channel regulation
@nl
prefLabel
Trafficking of TRPP2 by PACS p ...... nism of ion channel regulation
@ast
Trafficking of TRPP2 by PACS p ...... nism of ion channel regulation
@en
Trafficking of TRPP2 by PACS p ...... nism of ion channel regulation
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P2093
P2860
P50
P921
P356
P1433
P1476
Trafficking of TRPP2 by PACS p ...... nism of ion channel regulation
@en
P2093
Björn Buchholz
Christoph Carl Tschucke
Gary Thomas
Katia Carmine Simmen
Katja Höpker
Michael Köttgen
Richard Sandford
Robert Tauber
P2860
P304
P356
10.1038/SJ.EMBOJ.7600566
P407
P577
2005-02-23T00:00:00Z