Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis
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Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanismIRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calciumCoexpression of MAST205 inhibits the activity of Na+/H+ exchanger NHE3.NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activationMolecular mechanisms and regulation of urinary acidificationCarbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytesNHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranesMass spectrometry analysis of the native protein complex containing actinin-4 in prostate cancer cells.Cytosolic COOH terminus of the peptide transporter PEPT2 is involved in apical membrane localization of the protein.PKCα regulates vasopressin-induced aquaporin-2 trafficking in mouse kidney collecting duct cells in vitro via altering microtubule assembly.NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol.Na/H exchanger regulatory factors control parathyroid hormone receptor signaling by facilitating differential activation of G(alpha) protein subunits.Concerted actions of NHERF2 and WNK4 in regulating TRPV5Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell lines.Structural and functional characterization of the human NBC3 sodium/bicarbonate co-transporter carboxyl-terminal cytoplasmic domain.Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells.Uncovering the salt response of soybean by unraveling its wild and cultivated functional genomes using tag sequencing.Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border.NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles.NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli.Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activityForskolin Regulates L-Type Calcium Channel through Interaction between Actinin 4 and β3 Subunit in Osteoblasts.Regulation of ion transport by the NHERF family of PDZ proteins.PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes.Evolutionary origins of eukaryotic sodium/proton exchangers.NHERF family and NHE3 regulation.The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity.The emerging role of PDZ adapter proteins for regulation of intestinal ion transport.NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.The calcineurin homologous protein-1 increases Na(+)/H(+) -exchanger 3 trafficking via ezrin phosphorylationAlpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3.Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3NHE3 regulatory complexesRegulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium.Regulation of electroneutral NaCl absorption by the small intestine
P2860
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P2860
Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@ast
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@en
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@en-gb
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
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type
label
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@ast
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@en
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@en-gb
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@nl
prefLabel
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@ast
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@en
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@en-gb
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
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P2093
P2860
P356
P1476
Ca(2+)-dependent inhibition of ...... ligomerization and endocytosis
@en
P2093
C H Chris Yun
Jae Ho Kim
Jong Bae Park
Mark Donowitz
Whaseon Lee-Kwon
P2860
P304
23714-23724
P356
10.1074/JBC.M200835200
P407
P50
P577
2002-04-10T00:00:00Z