Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function
about
Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotectionVimentin is a novel AKT1 target mediating motility and invasionBimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosisDifferential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signalingRACK1 and CIS mediate the degradation of BimEL in cancer cellsThe Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationPhosphorylation of Puma modulates its apoptotic function by regulating protein stabilityRoles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistanceUbiquitin-proteasome system as a modulator of cell fate14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimenRegulation of Bim in Health and DiseaseSignaling cross-talk in the resistance to HER family receptor targeted therapyBIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cellsHypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell typesNerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of BimCyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim14-3-3theta protects against neurotoxicity in a cellular Parkinson's disease model through inhibition of the apoptotic factor BaxBIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutationsKnockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cellsIntrinsically disordered proteins in bcl-2 regulated apoptosis.High BIM mRNA levels are associated with longer survival in advanced gastric cancerBim, Bak, and Bax regulate osteoblast survival.Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells.Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification.TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEIRole for the proapoptotic factor BIM in mediating imatinib-induced apoptosis in a c-KIT-dependent gastrointestinal stromal tumor cell lineRational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growthSOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a.Bim nuclear translocation and inactivation by viral interferon regulatory factor.Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway.Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus.Lipid signaling in T-cell development and functionHuman herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry.Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.Glucocorticoid-mediated repression of the oncogenic microRNA cluster miR-17~92 contributes to the induction of Bim and initiation of apoptosisConcurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma.S6 kinase 2 promotes breast cancer cell survival via Akt.Antitumor activity of S116836, a novel tyrosine kinase inhibitor, against imatinib-resistant FIP1L1-PDGFRα-expressing cellsRoles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging.
P2860
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P2860
Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@ast
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@en
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@en-gb
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@nl
type
label
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@ast
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@en
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@en-gb
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@nl
prefLabel
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@ast
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@en
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@en-gb
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@nl
P2093
P2860
P3181
P356
P1476
Evidence that Ser87 of BimEL i ...... lates BimEL apoptotic function
@en
P2093
Gary M Wildey
Philip H Howe
Xiao-Jun Qi
P2860
P304
P3181
P356
10.1074/JBC.M505546200
P407
P577
2006-01-13T00:00:00Z