The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
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Genome-wide prediction and validation of peptides that bind human prosurvival Bcl-2 proteinsBcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimersEvidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic functiontBid undergoes multiple conformational changes at the membrane required for Bax activationInteraction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosisProapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.Functional and structural studies of the vaccinia virus virulence factor N1 reveal a Bcl-2-like anti-apoptotic proteinStructural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xLVaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family proteinVaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligandsMutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosisThe Bcl-2 apoptotic switch in cancer development and therapyProapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activityChondrocyte Apoptosis in the Pathogenesis of OsteoarthritisDynamics of Bcl-xL in water and membrane: molecular simulationsCrystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only proteinStructural insights into the degradation of Mcl-1 induced by BH3 domainsCrystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 familyA novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradationStructural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than ApoptosisMolecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with BimHigh-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xLConformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind LigandsMcl-1-Bim complexes accommodate surprising point mutations via minor structural changesDeterminants of BH3 Binding Specificity for Mcl-1 versus Bcl-xLEvidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAXStructural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based DesignEvaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 DomainPUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosisStructural Insights of tBid, the Caspase-8-activated Bid, and Its BH3 DomainTargeting -Herpesvirus 68 Bcl-2-mediated Down-regulation of AutophagyThe DNA-binding domain mediates both nuclear and cytosolic functions of p53Structural Insight into BH3 Domain Binding of Vaccinia Virus Antiapoptotic F1LBh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysisBuilding blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosisConstitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cellsBcL-xL conformational changes upon fragment binding revealed by NMR
P2860
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P2860
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
@ast
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
@en
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
@nl
type
label
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
@ast
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
@en
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
@nl
prefLabel
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
@ast
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
@en
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
@nl
P2093
P3181
P1433
P1476
The structure of a Bcl-xL/Bim fragment complex: implications for Bim function
@en
P2093
Shaodong Dai
P304
P3181
P356
10.1016/S1074-7613(03)00234-6
P407
P577
2003-09-01T00:00:00Z