Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signalingRNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signallingStructural basis of selective ubiquitination of TRF1 by SCFFbx4A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor proteinHypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alphaErythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor prolineStructure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alphaNEDD8 acts as a 'molecular switch' defining the functional selectivity of VHLCellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitinationProlyl 4-hydroxylaseDiversity of degradation signals in the ubiquitin-proteasome systemNovel exon 12 mutations in the HIF2A gene associated with erythrocytosisThe Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plateHypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylationSequence and structural analysis of BTB domain proteinsAscorbate depletion: a critical step in nickel carcinogenesis?The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functionsTargeting Protein-Protein Interactions in the HIF SystemMotif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulationThe hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regenerationStructural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factorThe Structure of YqeH: AN AtNOS1/AtNOA1 ORTHOLOG THAT COUPLES GTP HYDROLYSIS TO MOLECULAR RECOGNITIONDissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein InterfaceRecognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitinationTargeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α InteractionA novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligasePHD2: from hypoxia regulation to disease progressionThe LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancerDisruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activityGenetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromiumThe SCF ubiquitin ligase: insights into a molecular machineSolution structure of the human ubiquitin-specific protease 15 DUSP domainSubstrate-mediated regulation of cullin neddylationIdentification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzymeComprehensive assessment of cancer missense mutation clustering in protein structuresCapturing cooperative interactions with the PSI-MI format
P2860
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P2860
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@ast
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@en
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@en-gb
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@nl
type
label
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@ast
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@en
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@en-gb
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@nl
prefLabel
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@ast
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@en
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@en-gb
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@nl
P2093
P3181
P356
P1433
P1476
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling
@en
P2093
Frank Gertler
Haifeng Yang
Jung-Hyun Min
Mircea Ivan
Nikola P Pavletich
P304
P3181
P356
10.1126/SCIENCE.1073440
P407
P577
2002-06-07T00:00:00Z