Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
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Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygenStructural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediatesScreening chelating inhibitors of HIF-prolyl hydroxylase domain 2 (PHD2) and factor inhibiting HIF (FIH)Hypoxia-based strategies for angiogenic induction: the dawn of a new era for ischemia therapy and tissue regenerationProlyl 4-hydroxylaseStudies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assayA novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding grooveDNA Tumor Viruses and Cell MetabolismTargeting Protein-Protein Interactions in the HIF SystemGrowing with the wind. Ribosomal protein hydroxylation and cell growthThermal unfolding pathway of PHD2 catalytic domain in three different PHD2 species: computational approachesThe Crystal Structure of an Algal Prolyl 4-Hydroxylase Complexed with a Proline-rich Peptide Reveals a Novel Buried Tripeptide Binding MotifThe active site of an algal prolyl 4-hydroxylase has a large structural plasticityCrystal Structure of Prolyl 4-Hydroxylase from Bacillus anthracisCrystal structure of Tpa1 from Saccharomyces cerevisiae, a component of the messenger ribonucleoprotein complexSelective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic ApproachesAb Initio Structural Modeling of and Experimental Validation for Chlamydia trachomatis Protein CT296 Reveal Structural Similarity to Fe(II) 2-Oxoglutarate-Dependent EnzymesInvestigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygenAn inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cellsStructural and functional insights into Saccharomyces cerevisiae Tpa1, a putative prolylhydroxylase influencing translation termination and transcription.Inhibition of 2-oxoglutarate dependent oxygenasesThe putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylationPotent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine BrainThe role of PHD2 mutations in the pathogenesis of erythrocytosis.The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerensMetal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha proteinLATERAL BRANCHING OXIDOREDUCTASE acts in the final stages of strigolactone biosynthesis in ArabidopsisImposing function down a (cupin)-barrel: secondary structure and metal stereochemistry in the αKG-dependent oxygenases.Functional characterization of an orphan cupin protein from Burkholderia xenovorans reveals a mononuclear nonheme Fe2+-dependent oxygenase that cleaves beta-diketones.High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma.Distribution and prediction of catalytic domains in 2-oxoglutarate dependent dioxygenases.The atomic resolution structure of human AlkB homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolismKinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.A yeast three-hybrid system that reconstitutes mammalian hypoxia inducible factor regulatory machineryOGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling.Molecular markers of paragangliomas/pheochromocytomasIron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity.Targeting iron metabolism in drug discovery and deliveryTumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.Nanoscopy of the cellular response to hypoxia by means of fluorescence resonance energy transfer (FRET) and new FRET software
P2860
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P2860
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
description
2006 nî lūn-bûn
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2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2006 թվականի հունիսին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Cellular oxygen sensing: Cryst ...... ctor prolyl hydroxylase (PHD2)
@ast
Cellular oxygen sensing: Cryst ...... ctor prolyl hydroxylase (PHD2)
@en
Cellular oxygen sensing: Cryst ...... ctor prolyl hydroxylase (PHD2)
@nl
type
label
Cellular oxygen sensing: Cryst ...... ctor prolyl hydroxylase (PHD2)
@ast
Cellular oxygen sensing: Cryst ...... ctor prolyl hydroxylase (PHD2)
@en
Cellular oxygen sensing: Cryst ...... ctor prolyl hydroxylase (PHD2)
@nl
prefLabel
Cellular oxygen sensing: Cryst ...... ctor prolyl hydroxylase (PHD2)
@ast
Cellular oxygen sensing: Cryst ...... ctor prolyl hydroxylase (PHD2)
@en
Cellular oxygen sensing: Cryst ...... ctor prolyl hydroxylase (PHD2)
@nl
P2093
P2860
P50
P921
P356
P1476
Cellular oxygen sensing: Cryst ...... ctor prolyl hydroxylase (PHD2)
@en
P2093
Benoît M R Liénard
Christopher Mohr
Evelyn Yang
Ian J Clifton
James Zondlo
Jeffrey Lewis
Kirsty S Hewitson
Luke A McNeill
Rashid S Syed
Robert J M Kurzeja
P2860
P304
P356
10.1073/PNAS.0601283103
P407
P577
2006-06-27T00:00:00Z