Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
about
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG islandSirtuins: Sir2-related NAD-dependent protein deacetylasesp53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylaseEpigenetic regulation of caloric restriction in agingSirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcriptionThe flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylasesModulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gammaSilent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activityMageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBsInteractions between E2F1 and SirT1 regulate apoptotic response to DNA damageIdentification and characterization of SAP25, a novel component of the mSin3 corepressor complex.PML regulates PER2 nuclear localization and circadian functionSirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptorRegulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylationSIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stabilityDrosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor proteinNegative regulation of the deacetylase SIRT1 by DBC1Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteinsSIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cellsCK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damagehSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damagep53 regulates Period2 expression and the circadian clockCrystal structures of human SIRT3 displaying substrate-induced conformational changesSIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activitiesSUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PMLThe mammalian SIR2alpha protein has a role in embryogenesis and gametogenesisSirtuins deacetylate and activate mammalian acetyl-CoA synthetasesStructural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylasesEffect of nitroxoline on angiogenesis and growth of human bladder cancerSRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repressionBCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repressionmiR-34a repression of SIRT1 regulates apoptosisSIRT6 in DNA repair, metabolism and ageingExpression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissuesSirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stressThe 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases
P2860
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P248
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P2860
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
@nl
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
@ast
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
@en
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
@en-gb
type
label
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
@nl
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
@ast
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
@en
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
@en-gb
prefLabel
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
@nl
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
@ast
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
@en
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
@en-gb
P2093
P2860
P921
P3181
P356
P1433
P1476
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
@en
P2093
Emma Langley
Mark Pearson
Pier Giuseppe Pelicci
Roy A Frye
Saverio Minucci
Tony Kouzarides
Uta-Maria Bauer
P2860
P304
P3181
P356
10.1093/EMBOJ/21.10.2383
P407
P577
2002-05-01T00:00:00Z