EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response
about
Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase.The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin.Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip214-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.The N-end rule pathwaySolution structure of the C-terminal domain from poly(A)-binding protein inTrypanosoma cruzi: A vegetal PABC domainStructural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDDStructure of the HECT C-lobe of the UBR5 E3 ubiquitin ligaseEDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancerEDD mediates DNA damage-induced activation of CHK2Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD functionEDD enhances cell survival and cisplatin resistance and is a therapeutic target for epithelial ovarian cancer.HECT E3s and human disease.Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatinModulation of myocardin function by the ubiquitin E3 ligase UBR5.UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function.EDD inhibits ATM-mediated phosphorylation of p53.A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis.Regulation of hedgehog Ligand Expression by the N-End Rule Ubiquitin-Protein Ligase Hyperplastic Discs and the Drosophila GSK3β Homologue, Shaggy.Human Herpesvirus-6 U14 Induces Cell-Cycle Arrest in G2/M Phase by Associating with a Cellular Protein, EDD.Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development.A novel role for RIP1 kinase in mediating TNFα production.The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression.The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitroEdd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion.Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-α protein levels and activity.E3 ubiquitin ligase isolated by differential display regulates cervical cancer growth in vitro and in vivo via microRNA-143.CIB1: a small protein with big ambitions.E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60.Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.Cloning and identification of EDD gene from ultraviolet-irradiated HaCaT cells.Cep78 controls centrosome homeostasis by inhibiting EDD-DYRK2-DDB1VprBP.EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole.Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD.Calcium- and magnesium-dependent interactions between calcium- and integrin-binding protein and the integrin alphaIIb cytoplasmic domain.Significance of the E3 ubiquitin protein UBR5 as an oncogene and a prognostic biomarker in colorectal cancer.Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5.The p90 ribosomal S6 kinase-UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor-associated factor 3.MOAP-1, UBR5 and cisplatin resistance in ovarian cancer.
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P248
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P2860
EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response
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2002 nî lūn-bûn
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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
EDD, the human hyperplastic di ...... lvement in DNA damage response
@ast
EDD, the human hyperplastic di ...... lvement in DNA damage response
@en
EDD, the human hyperplastic di ...... lvement in DNA damage response
@en-gb
EDD, the human hyperplastic di ...... lvement in DNA damage response
@nl
type
label
EDD, the human hyperplastic di ...... lvement in DNA damage response
@ast
EDD, the human hyperplastic di ...... lvement in DNA damage response
@en
EDD, the human hyperplastic di ...... lvement in DNA damage response
@en-gb
EDD, the human hyperplastic di ...... lvement in DNA damage response
@nl
prefLabel
EDD, the human hyperplastic di ...... lvement in DNA damage response
@ast
EDD, the human hyperplastic di ...... lvement in DNA damage response
@en
EDD, the human hyperplastic di ...... lvement in DNA damage response
@en-gb
EDD, the human hyperplastic di ...... lvement in DNA damage response
@nl
P2093
P2860
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EDD, the human hyperplastic di ...... lvement in DNA damage response
@en
P2093
Amanda J Russell
Colin K W Watts
David A Jans
Gillian M Lehrbach
Jennifer L Clancy
Marcia Muñoz
Michelle J Henderson
Robert L Sutherland
Samantha Hird
Sophina T Calanni
P2860
P304
P3181
P356
10.1074/JBC.M203527200
P407
P577
2002-07-19T00:00:00Z