G9a and Glp methylate lysine 373 in the tumor suppressor p53 - Test2 - elhamkhani - TriplyDB

G9a and Glp methylate lysine 373 in the tumor suppressor p53

G9a and Glp methylate lysine 373 in the tumor suppressor p53

http://www.wikidata.org/entity/Q24298004

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Methylation of the retinoblastoma tumor suppressor by SMYD2 H3K9 histone methyltransferase G9a-mediated transcriptional activation of p21 A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Functional Role of G9a Histone Methyltransferase in Cancer Chemical probes of histone lysine methyltransferases The functional diversity of protein lysine methylation An unexpected journey: lysine methylation across the proteome Current chemical biology approaches to interrogate protein methyltransferases Protein methylation at the surface and buried deep: thinking outside the histone box The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression Structure of Human SMYD2 Protein Reveals the Basis of p53 Tumor Suppressor Methylation Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a Histone lysine methyltransferases as anti-cancer targets for drug discovery Histone methylation modifiers in cellular signaling pathways Epigenetic regulation of autophagy by the methyltransferase G9a Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase The selective activation of p53 target genes regulated by SMYD2 in BIX-01294 induced autophagy-related cell death Assay development for histone methyltransferases.Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2.Accessing protein methyltransferase and demethylase enzymology using microfluidic capillary electrophoresis A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response.Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53 Modulation of microRNA expression in human lung cancer cells by the G9a histone methyltransferase inhibitor BIX01294.Inhibition of G9a induces DUSP4-dependent autophagic cell death in head and neck squamous cell carcinoma.Fluorescence-based methods for screening writers and readers of histone methyl marks.Efficient hit-finding approaches for histone methyltransferases: the key parameters.Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output Current limitations and future opportunities for epigenetic therapies.Substrate and product specificities of SET domain methyltransferases Plant homeodomain finger protein 2 promotes bone formation by demethylating and activating Runx2 for osteoblast differentiation The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth.p53 post-translational modification: deregulated in tumorigenesis An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1 Writing and rewriting the epigenetic code of cancer cells: from engineered proteins to small molecules Making sense of ubiquitin ligases that regulate p53.Small-molecular modulators of cancer-associated epigenetic mechanisms.The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis.

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P2860

G9a and Glp methylate lysine 373 in the tumor suppressor p53

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description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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JBC.M109.062588

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Journal of Biological Chemistry

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

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Jean Dorsey

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Jing Huang

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Laura Pérez-Burgos

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Sergei Chuikov

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Shelley L Berger

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Thomas Jenuwein

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Xinyue Zhang

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P2860

p53 is regulated by the lysine demethylase LSD1

Regulation of p53 activity through lysine methylation

Acetylation is indispensable for p53 activation

Repression of p53 activity by Smyd2-mediated methylation

Modulation of p53 function by SET8-mediated methylation at lysine 382

A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

ONCOMINE: a cancer microarray database and integrated data-mining platform

Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

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686673

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10.1074/JBC.M109.062588

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13

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285

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41191289

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20118233

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peptidyl-lysine dimethylation

Euchromatic histone lysine methyltransferase 2

Euchromatic histone lysine methyltransferase 1

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