A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
about
Studying epigenetic complexes and their inhibitors with the proteomics toolboxTargeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesFunctional Role of G9a Histone Methyltransferase in CancerOpen access chemical probes for epigenetic targetsSynthesis of lysine methyltransferase inhibitorsChemical probes of histone lysine methyltransferasesDesign of small molecule epigenetic modulatorsHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionCurrent chemical biology approaches to interrogate protein methyltransferasesCancer epigenetics drug discovery and development: the challenge of hitting the markAn Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji DemethylasesDiscovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9aAssembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocationKRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.Cell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activityHistone lysine methyltransferases as anti-cancer targets for drug discoveryThe emerging role of lysine methyltransferase SETD8 in human diseasesEpigenetic regulation of autophagy by the methyltransferase G9aDiscovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.Inhibition of euchromatic histone methyltransferase 1 and 2 sensitizes chronic myeloid leukemia cells to interferon treatmentFunctional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)Open access target validation is a more efficient way to accelerate drug discoveryGain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug SensitivityPolymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural featuresG9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 statusGenome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability.Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesSilencing of odorant receptor genes by G protein βγ signaling ensures the expression of one odorant receptor per olfactory sensory neuron.Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferationAnalogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2.Chemical probes targeting epigenetic proteins: Applications beyond oncology.Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.Epigenetic regulation of epithelial-mesenchymal transitionCancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance.Composition and applications of focus libraries to phenotypic assaysChromatin proteins and modifications as drug targets.The use of small molecules in somatic-cell reprogramming.Fluorescence-based methods for screening writers and readers of histone methyl marks.
P2860
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P2860
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
@ast
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
@en
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
@nl
type
label
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
@ast
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
@en
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
@nl
prefLabel
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
@ast
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
@en
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
@nl
P2093
P2860
P50
P3181
P356
P1476
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
@en
P2093
Aiping Dong
Arturas Petronis
Ashutosh Tripathy
Benjamin A Garcia
Bryan L Roth
Catherine D Simpson
Dmitri B Kireev
Irene Chau
Jacqueline L Norris
P2860
P2888
P304
P3181
P356
10.1038/NCHEMBIO.599
P407
P50
P577
2011-08-01T00:00:00Z
P5875
P6179
1002547330