Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG
about
Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptideNucleotide excision repair in eukaryotesUnpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleasesStructural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPAHuman Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 SuperfamilyRecognition and repair of the cyclobutane thymine dimer, a major cause of skin cancers, by the human excision nuclease.Ordered conformational changes in damaged DNA induced by nucleotide excision repair factors.Mechanism of Holliday junction resolution by the human GEN1 proteinFunctional regulation of FEN1 nuclease and its link to cancerA general path for large-scale solubilization of cellular proteins: from membrane receptors to multiprotein complexes.The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndromeNeutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ionsRepeat instability during DNA repair: Insights from model systemsDomain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity.Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends.Molecular mechanisms of xeroderma pigmentosum (XP) proteins.Expression of XPG protein in human normal and tumor tissues.The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damageCoordination of dual incision and repair synthesis in human nucleotide excision repair.XPG: its products and biological roles.Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damage.Regulation of endonuclease activity in human nucleotide excision repair.Molecular mechanism of global genome nucleotide excision repair.FEN1 participates in repair of the 5'-phosphotyrosyl terminus of DNA single-strand breaks.Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.The mycobacteriophage D29 gene 65 encodes an early-expressed protein that functions as a structure-specific nuclease.The spacer region of XPG mediates recruitment to nucleotide excision repair complexes and determines substrate specificity.Nucleotide excision repair eliminates unique DNA-protein cross-links from mammalian cells.Interaction interface of human flap endonuclease-1 with its DNA substrates.
P2860
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P2860
Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structural determinants for su ...... ture-specific endonuclease XPG
@ast
Structural determinants for su ...... ture-specific endonuclease XPG
@en
Structural determinants for su ...... ture-specific endonuclease XPG
@en-gb
Structural determinants for su ...... ture-specific endonuclease XPG
@nl
type
label
Structural determinants for su ...... ture-specific endonuclease XPG
@ast
Structural determinants for su ...... ture-specific endonuclease XPG
@en
Structural determinants for su ...... ture-specific endonuclease XPG
@en-gb
Structural determinants for su ...... ture-specific endonuclease XPG
@nl
prefLabel
Structural determinants for su ...... ture-specific endonuclease XPG
@ast
Structural determinants for su ...... ture-specific endonuclease XPG
@en
Structural determinants for su ...... ture-specific endonuclease XPG
@en-gb
Structural determinants for su ...... ture-specific endonuclease XPG
@nl
P2093
P2860
P356
P1476
Structural determinants for su ...... ture-specific endonuclease XPG
@en
P2093
Fabrizio Thorel
Marcel Hohl
Orlando D Schärer
Stuart G Clarkson
P2860
P304
P356
10.1074/JBC.M213155200
P407
P577
2003-05-23T00:00:00Z