Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
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The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathwayAmyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS developmentAmyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastinPathophysiological Function of ADAMTS Enzymes on Molecular Mechanism of Alzheimer's DiseaseTransient dynamics of Aβ contribute to toxicity in Alzheimer's diseaseAlzheimer's therapeutics: translation of preclinical science to clinical drug developmentγ-Secretase inhibitors and modulators.Structural evolution and membrane interactions of Alzheimer's amyloid-beta peptide oligomers: new knowledge from single-molecule fluorescence studiesSynaptic dysfunction and septin protein family members in neurodegenerative diseasesMutations, associated with early-onset Alzheimer's disease, discovered in Asian countriesIdentification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid betaAmyloid-β protofibrils: size, morphology and synaptotoxicity of an engineered mimicAftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?Modification of a small β-barrel protein, to give pseudo-amyloid structures, inhibits amyloid β-peptide aggregation.β-sheet propensity controls the kinetic pathways and morphologies of seeded peptide aggregation.Recent progress in understanding Alzheimer's β-amyloid structures.Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriersR-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease.Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models.A new structural model of Alzheimer's Aβ42 fibrils based on electron paramagnetic resonance data and Rosetta modelingEffects of membrane interaction and aggregation of amyloid β-peptide on lipid mobility and membrane domain structure.Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosisThe complexities underlying age-related macular degeneration: could amyloid beta play an important role?Evaluation of plant phenolic metabolites as a source of Alzheimer's drug leads.Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats.Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.A peptide that binds specifically to the β-amyloid of Alzheimer's disease: selection and assessment of anti-β-amyloid neurotoxic effects.Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in miceModulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's diseaseAmyloid peptide Aβ40 inhibits aggregation of Aβ42: evidence from molecular dynamics simulations.The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa.Prolonged exposure of cortical neurons to oligomeric amyloid-β impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate.Aβ42-binding peptoids as amyloid aggregation inhibitors and detection ligands.Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease.Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaquesSynergistic interactions between Alzheimer's Aβ40 and Aβ42 on the surface of primary neurons revealed by single molecule microscopy.Plasma Aβ and PET PiB binding are inversely related in mild cognitive impairment.Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay
P2860
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P2860
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Neurotoxicity of Alzheimer's d ...... nges in the Aβ42 to Aβ40 ratio
@ast
Neurotoxicity of Alzheimer's d ...... nges in the Aβ42 to Aβ40 ratio
@en
Neurotoxicity of Alzheimer's d ...... nges in the Aβ42 to Aβ40 ratio
@nl
type
label
Neurotoxicity of Alzheimer's d ...... nges in the Aβ42 to Aβ40 ratio
@ast
Neurotoxicity of Alzheimer's d ...... nges in the Aβ42 to Aβ40 ratio
@en
Neurotoxicity of Alzheimer's d ...... nges in the Aβ42 to Aβ40 ratio
@nl
prefLabel
Neurotoxicity of Alzheimer's d ...... nges in the Aβ42 to Aβ40 ratio
@ast
Neurotoxicity of Alzheimer's d ...... nges in the Aβ42 to Aβ40 ratio
@en
Neurotoxicity of Alzheimer's d ...... nges in the Aβ42 to Aβ40 ratio
@nl
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
Neurotoxicity of Alzheimer's d ...... nges in the Aβ42 to Aβ40 ratio
@en
P2093
Annelies Vandersteen
Carmen Bartic
Dries Braeken
Frederic Rousseau
Geert Callewaert
Ine Segers-Nolten
Inna Kuperstein
Iryna Benilova
Kees Van Der Werf
Kerensa Broersen
P2860
P304
P3181
P356
10.1038/EMBOJ.2010.211
P407
P577
2010-10-06T00:00:00Z