Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.
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Virtual and In Vitro Screens Reveal a Potential Pharmacophore that Avoids the Fibrillization of Aβ1-42Numerical Simulations Reveal Randomness of Cu(II) Induced Aβ Peptide Dimerization under Conditions Present in Glutamatergic SynapsesAn Atomistic View of Amyloidogenic Self-assembly: Structure and Dynamics of Heterogeneous Conformational States in the Pre-nucleation Phase.Maximally asymmetric transbilayer distribution of anionic lipids alters the structure and interaction with lipids of an amyloidogenic protein dimer bound to the membrane surfaceLattice model for amyloid peptides: OPEP force field parametrization and applications to the nucleus size of Alzheimer's peptides.Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization.Decoding Structural Properties of a Partially Unfolded Protein Substrate: En Route to Chaperone Binding.Picosecond melting of peptide nanotubes using an infrared laser: a nonequilibrium simulation study.Picosecond dissociation of amyloid fibrils with infrared laser: A nonequilibrium simulation study.Effect of Copper and Zinc on the Single Molecule Self-Affinity of Alzheimer's Amyloid-β Peptides.Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study.The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments.Study of structural stability and damaging effect on membrane for four Aβ42 dimers.Induced Dipole-Dipole Interactions Influence the Unfolding Pathways of Wild-Type and Mutant Amyloid β-Peptides.Steric Crowding of the Turn Region Alters the Tertiary Fold of Amyloid-β18-35 and Makes It Soluble.Amylin-Aβ oligomers at atomic resolution using molecular dynamics simulations: a link between Type 2 diabetes and Alzheimer's diseaseAllosteric stabilization of the amyloid-β peptide hairpin by the fluctuating N-terminal.X-ray Crystallographic Structure of Oligomers Formed by a Toxic β-Hairpin Derived from α-Synuclein: Trimers and Higher-Order Oligomers.AChE Inhibition-based Multi-target-directed Ligands, a Novel Pharmacological Approach for the Symptomatic and Disease-modifying Therapy of Alzheimer's Disease.Amyloid-β 1-24 C-terminal truncated fragment promotes amyloid-β 1-42 aggregate formation in the healthy brain.Exploring the aggregation free energy landscape of the amyloid-β protein (1-40).Polymorphism of fibrillar structures depending on the size of assembled Aβ17-42 peptides.Structure of ring-shaped Aβ₄₂ oligomers determined by conformational selection.Molecular insights into Aβ42 protofibril destabilization with a fluorinated compound D744: A molecular dynamics simulation study.An Account of Amyloid Oligomers: Facts and Figures Obtained from Experiments and Simulations.High-Resolution Structures of the Amyloid-β 1-42 Dimers from the Comparison of Four Atomistic Force Fields.Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy.β-Amyloid-acetylcholine molecular interaction: new role of cholinergic mediators in anti-Alzheimer therapy?Multiscale simulation of molecular processes in cellular environments.Recent Progress in Alzheimer's Disease Research, Part 1: Pathology.Glycation induces conformational changes in the amyloid-β peptide and enhances its aggregation propensity: molecular insights.Comparison of force fields for Alzheimer's A β42: A case study for intrinsically disordered proteins.HP-β-cyclodextrin as an inhibitor of amyloid-β aggregation and toxicity.Fullerenol C60(OH)16 prevents amyloid fibrillization of Aβ40-in vitro and in silico approach.The structure of chromophore-grafted amyloid-β(12-28) dimers in the gas-phase: FRET-experiment guided modelling.Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp.Lipid insertion domain unfolding regulates protein orientational transition behavior in a lipid bilayer.Conformational-Sensitive Fast Photochemical Oxidation of Proteins and Mass Spectrometry Characterize Amyloid Beta 1-42 AggregationMolecular Dynamics Simulations of Amyloid β-Peptide (1-42): Tetramer Formation and Membrane InteractionsMembrane-Accelerated Amyloid-β Aggregation and Formation of Cross-β Sheets.
P2860
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P2860
Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.
description
2015 nî lūn-bûn
@nan
2015 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մարտին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Amyloid β Protein and Alzheime ...... mplement Experimental Studies.
@ast
Amyloid β Protein and Alzheime ...... mplement Experimental Studies.
@en
type
label
Amyloid β Protein and Alzheime ...... mplement Experimental Studies.
@ast
Amyloid β Protein and Alzheime ...... mplement Experimental Studies.
@en
prefLabel
Amyloid β Protein and Alzheime ...... mplement Experimental Studies.
@ast
Amyloid β Protein and Alzheime ...... mplement Experimental Studies.
@en
P2093
P2860
P50
P356
P1433
P1476
Amyloid β Protein and Alzheime ...... mplement Experimental Studies.
@en
P2093
Alfonso De Simone
Anant Paravastu
Angel Garcia
Bogdan Tarus
Chunyu Wang
David J Rosenman
Fabio Sterpone
Jessica Nasica-Labouze
John H Viles
Olivia Berthoumieu
P2860
P304
P356
10.1021/CR500638N
P50
P577
2015-03-19T00:00:00Z