TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
about
The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitroThe dystonia-associated protein torsinA modulates synaptic vesicle recyclingBiosynthesis of the dystonia-associated AAA+ ATPase torsinA at the endoplasmic reticulumEffect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutantThe early onset dystonia protein torsinA interacts with kinesin light chain 1LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutationTorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeletonPrintor, a novel torsinA-interacting protein implicated in dystonia pathogenesisUnscrambling an egg: protein disaggregation by AAA+ proteinsGene Expression and MicroRNA Expression Analysis in Small Arteries of Spontaneously Hypertensive Rats. Evidence for ER StressTorsins: not your typical AAA+ ATPasesDystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelopeEarlier onset of motor deficits in mice with double mutations in Dyt1 and Sgce.Chemical enhancement of torsinA function in cell and animal models of torsion dystonia.The BiP molecular chaperone plays multiple roles during the biogenesis of torsinA, an AAA+ ATPase associated with the neurological disease early-onset torsion dystonia.TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast.Biochemical and cellular analysis of human variants of the DYT1 dystonia protein, TorsinA/TOR1AThe early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response.Current Gaps in the Understanding of the Subcellular Distribution of Exogenous and Endogenous Protein TorsinA.A unique redox-sensing sensor II motif in TorsinA plays a critical role in nucleotide and partner binding.TorsinA in the nuclear envelope.DYT1 knock-in mice are not sensitized against mitochondrial complex-II inhibition.Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells.Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunctionCommentary: Dopaminergic dysfunction in DYT1 dystonia.Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum.Dopamine receptor and Gα(olf) expression in DYT1 dystonia mouse models during postnatal development.Mislocalization to the nuclear envelope: an effect of the dystonia-causing torsinA mutation.The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress.TorsinA participates in endoplasmic reticulum-associated degradationThe torsin-family AAA+ protein OOC-5 contains a critical disulfide adjacent to Sensor-II that couples redox state to nucleotide binding.Site-specific Proteolysis Mobilizes TorsinA from the Membrane of the Endoplasmic Reticulum (ER) in Response to ER Stress and B Cell Stimulation.Identifying the genetic components underlying the pathophysiology of movement disorders.Glial elements contribute to stress-induced torsinA expression in the CNS and peripheral nervous systemInteraction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion.Primary dystonia: molecules and mechanisms.Molecular pathways in dystonia.Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins.Membrane defects and genetic redundancy: Are we at a turning point for DYT1 dystonia?Exploring the influence of torsinA expression on protein quality control.
P2860
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P2860
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
description
2003 nî lūn-bûn
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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
@ast
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
@en
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
@nl
type
label
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
@ast
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
@en
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
@nl
prefLabel
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
@ast
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
@en
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
@nl
P2093
P3181
P356
P1476
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress
@en
P2093
Christoph Kamm
Damien Slater
Daniele Bergeron
Deborah Schuback
Heather Boston
Jeffrey Hewett
Jeremy Wilbur
Laurie J Ozelius
Nicole Smith
Philipp Ziefer
P304
P3181
P356
10.1002/JNR.10567
P407
P577
2003-04-15T00:00:00Z