The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro
about
Structural features and chaperone activity of the NudC protein family.Torsins: not your typical AAA+ ATPasesEarlier onset of motor deficits in mice with double mutations in Dyt1 and Sgce.TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegenerationGene expression of behaviorally relevant genes in the cerebral hemisphere changes after selection for tameness in Red Junglefowl.Altered dendritic morphology of Purkinje cells in Dyt1 ΔGAG knock-in and purkinje cell-specific Dyt1 conditional knockout mice.TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast.Motor deficits and decreased striatal dopamine receptor 2 binding activity in the striatum-specific Dyt1 conditional knockout miceThe early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response.Untethering the nuclear envelope and cytoskeleton: biologically distinct dystonias arising from a common cellular dysfunctionDecreased dopamine receptor 1 activity and impaired motor-skill transfer in Dyt1 ΔGAG heterozygous knock-in mice.Pre-synaptic release deficits in a DYT1 dystonia mouse model.Rapid genotyping of animals followed by establishing primary cultures of brain neurons.Invertebrate models of dystonia.Site-specific Proteolysis Mobilizes TorsinA from the Membrane of the Endoplasmic Reticulum (ER) in Response to ER Stress and B Cell Stimulation.Engineering animal models of dystoniaDisruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis.Molecular pathways in dystonia.Early-onset torsion dystonia: a novel high-throughput yeast genetic screen for factors modifying protein levels of torsinAΔE.TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement.A functional role for TorsinA in herpes simplex virus 1 nuclear egress.Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins.Understanding dystonia: diagnostic issues and how to overcome them.Exploring the influence of torsinA expression on protein quality control.LINCing defective nuclear-cytoskeletal coupling and DYT1 dystonia.Human TorsinA can function in the yeast cytosol as a molecular chaperone.Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for Dystonia.TorsinA dysfunction causes persistent neuronal nuclear pore defects.Miniature release events of glutamate from hippocampal neurons are influenced by the dystonia-associated protein torsinA.
P2860
Q27667619-C4553B22-3148-456B-9F13-D5BE9482C6EEQ28087663-EDD5D7D0-2118-4532-B711-7DAA9753BB89Q30497374-66942C7B-9C70-4D17-B412-F680B922EE4CQ30581663-95599F65-F625-4278-97AD-728FFEFE30BDQ33648218-6A2A065D-A262-40B9-98B4-C45BBB0D772BQ33867544-6E69FB79-FA20-45A3-87B9-5AE7B32E4579Q33983398-3D2A7ACD-5ACA-4709-AB81-9214D464435BQ34023627-F55849C4-30EF-4E4F-815E-248D0D01CA25Q34083670-DE82FC32-4F31-49BE-8293-0EDAAABEA9C1Q34638417-6430ED95-F2A5-485D-922A-F81EA7EF856AQ34866730-AC7E98C9-6BB5-497C-9DE9-5CD163CDA550Q34965241-8A587BC4-3033-4708-8C06-3F532F3D378FQ35161997-AE913BA3-22ED-4E14-871B-3AB52A2ED27FQ36634138-18A69ADA-DDBA-43B4-B692-C93FAA8060EEQ36849988-6B4B5495-27AF-45CF-9285-66CD63C2B1F3Q37239952-C89631E4-66BF-409F-BDB8-780DAE6F9CBEQ37310305-56DEE4E3-A73E-433F-852F-FE163C806CAFQ37816579-0DA64B80-B5FB-42A0-BD82-49C9F28BFC51Q38646083-5635733A-3BFC-419B-98EC-53857651F7B8Q38714582-F5869950-4029-40D7-B49F-9DDF2621F128Q38749086-086BA99F-D064-448C-8680-E7350671140FQ38976723-802E4FCC-E5DE-4059-B5FE-D3C80377C4D5Q39024386-EC6AA566-99C6-4B65-BF48-D78B334B5D93Q39619556-7F884C19-4C19-40F7-A3FB-AEECF6ED8FBFQ41785405-12829E8F-7BE7-4549-B38B-1CB1E59776E3Q42221182-D242F7A0-021B-433F-AFC7-5014B6E706E5Q47165495-381B6A63-BEB1-49EA-9DD6-8231B2C624FCQ47351833-2BD24B4E-3C6B-4CE8-979A-AC6260C3094AQ48161931-17A04A20-CB2B-46A2-A283-67B078F5BA3E
P2860
The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The early-onset torsion dyston ...... ar chaperone activity in vitro
@ast
The early-onset torsion dyston ...... ar chaperone activity in vitro
@en
The early-onset torsion dyston ...... ar chaperone activity in vitro
@en-gb
The early-onset torsion dyston ...... ar chaperone activity in vitro
@nl
type
label
The early-onset torsion dyston ...... ar chaperone activity in vitro
@ast
The early-onset torsion dyston ...... ar chaperone activity in vitro
@en
The early-onset torsion dyston ...... ar chaperone activity in vitro
@en-gb
The early-onset torsion dyston ...... ar chaperone activity in vitro
@nl
prefLabel
The early-onset torsion dyston ...... ar chaperone activity in vitro
@ast
The early-onset torsion dyston ...... ar chaperone activity in vitro
@en
The early-onset torsion dyston ...... ar chaperone activity in vitro
@en-gb
The early-onset torsion dyston ...... ar chaperone activity in vitro
@nl
P2093
P2860
P921
P1476
The early-onset torsion dyston ...... ar chaperone activity in vitro
@en
P2093
Alexander J Burdette
Guy A Caldwell
Kim A Caldwell
Perry F Churchill
P2860
P2888
P304
P356
10.1007/S12192-010-0173-2
P407
P577
2010-09-01T00:00:00Z
P5875
P6179
1038711884