A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation
about
The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and functionMitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cellsDNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cellsAutophagy mediates the mitotic senescence transitionSIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during agingSenescence of activated stellate cells limits liver fibrosisThe matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healingRemodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and agingLet-7 and miR-200 microRNAs: guardians against pluripotency and cancer progressionDNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositidesEpigenetic principles and mechanisms underlying nervous system functions in health and diseaseHmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf ExpressionMolecular dissection of formation of senescence-associated heterochromatin fociOld cells, new tricks: chromatin structure in senescenceMarkers of cellular senescence. Telomere shortening as a marker of cellular senescenceLinking replication stress with heterochromatin formationReplication Stress: A Lifetime of Epigenetic ChangeThe impact of cellular senescence in cancer therapy: is it true or not?Mechanisms of disseminated cancer cell dormancy: an awakening fieldTherapeutic targeting of replicative immortalityCell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Reorganization of chromosome architecture in replicative cellular senescenceStem cells, senescence, neosis and self-renewal in cancer.Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activityHuman UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.Physiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear EdgeStress induced premature senescence: a new culprit in ovarian tumorigenesis?A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-αMapping intact protein isoforms in discovery mode using top-down proteomicsCell fusion induced by ERVWE1 or measles virus causes cellular senescenceA versatile viral system for expression and depletion of proteins in mammalian cellsThe cell proliferation antigen Ki-67 organises heterochromatinHMGA1 pseudogenes as candidate proto-oncogenic competitive endogenous RNAsDysregulated ΔNp63α inhibits expression of Ink4a/arf, blocks senescence, and promotes malignant conversion of keratinocytesQuantitation and Identification of Thousands of Human Proteoforms below 30 kDaBlueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells.Lysosome-mediated processing of chromatin in senescence.Loss of WSTF results in spontaneous fluctuations of heterochromatin formation and resolution, combined with substantial changes to gene expression.Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescenceNOTCH1 mediates a switch between two distinct secretomes during senescence.
P2860
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P2860
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
A novel role for high-mobility ...... and heterochromatin formation
@ast
A novel role for high-mobility ...... and heterochromatin formation
@en
A novel role for high-mobility ...... and heterochromatin formation
@en-gb
A novel role for high-mobility ...... and heterochromatin formation
@nl
type
label
A novel role for high-mobility ...... and heterochromatin formation
@ast
A novel role for high-mobility ...... and heterochromatin formation
@en
A novel role for high-mobility ...... and heterochromatin formation
@en-gb
A novel role for high-mobility ...... and heterochromatin formation
@nl
prefLabel
A novel role for high-mobility ...... and heterochromatin formation
@ast
A novel role for high-mobility ...... and heterochromatin formation
@en
A novel role for high-mobility ...... and heterochromatin formation
@en-gb
A novel role for high-mobility ...... and heterochromatin formation
@nl
P2093
P50
P921
P3181
P1433
P1476
A novel role for high-mobility ...... and heterochromatin formation
@en
P2093
Agustin Chicas
Masako Narita
Michael P Myers
Sabrina Nuñez
Scott W Lowe
Stephen A Hearn
P304
P3181
P356
10.1016/J.CELL.2006.05.052
P407
P577
2006-08-11T00:00:00Z