Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity
about
SMYD proteins: key regulators in skeletal and cardiac muscle development and functionA novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of Caenorhabditis elegansLocalization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activityCrystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site ArchitectureStructural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA bindingCrystal Structures of Histone and p53 Methyltransferase SmyD2 Reveal a Conformational Flexibility of the Autoinhibitory C-Terminal DomainStructural and Functional Profiling of the Human Histone Methyltransferase SMYD3Structural and Functional Analysis of the DEAF-1 and BS69 MYND DomainsFunctional diversification of the RING finger and other binuclear treble clef domains in prokaryotes and the early evolution of the ubiquitin systemA Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in developmentLoss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profileHow chromatin-binding modules interpret histone modifications: lessons from professional pocket pickersStructure and Biophysics of CBFβ/RUNX and Its Translocation Products.CBFbeta is critical for AML1-ETO and TEL-AML1 activity.BS69/ZMYND11 C-Terminal Domains Bind and Inhibit EBNA2.t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.Novel RNA-binding properties of the MTG chromatin regulatory proteins.Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila modelAttenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential.The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV.Analysis of two domains with novel RNA-processing activities throws light on the complex evolution of ribosomal RNA biogenesis.Cooperation between RUNX1-ETO9a and novel transcriptional partner KLF6 in upregulation of Alox5 in acute myeloid leukemia.Smyd1 facilitates heart development by antagonizing oxidative and ER stress responses.RUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the makingTranscription factors, chromatin proteins and the diversification of HemipteraMolecular Dynamics Simulation Reveals Correlated Inter-Lobe Motion in Protein Lysine Methyltransferase SMYD2.RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndromeProlyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathwayMouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray.Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis.The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.Restoration of MYC-repressed targets mediates the negative effects of GM-CSF on RUNX1-ETO leukemogenicity.Core binding factor at the crossroads: determining the fate of the HSC.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.RUNX1-ETO induces a type I interferon response which negatively effects t(8;21)-induced increased self-renewal and leukemia development.Nuclear hormone receptor co-repressors: structure and function.Targeting transcription factor corepressors in tumor cells.
P2860
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P2860
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structural Basis for Recogniti ...... ibution to AML1/ETO's Activity
@nl
Structural basis for recogniti ...... ibution to AML1/ETO's activity
@ast
Structural basis for recogniti ...... ibution to AML1/ETO's activity
@en
type
label
Structural Basis for Recogniti ...... ibution to AML1/ETO's Activity
@nl
Structural basis for recogniti ...... ibution to AML1/ETO's activity
@ast
Structural basis for recogniti ...... ibution to AML1/ETO's activity
@en
prefLabel
Structural Basis for Recogniti ...... ibution to AML1/ETO's Activity
@nl
Structural basis for recogniti ...... ibution to AML1/ETO's activity
@ast
Structural basis for recogniti ...... ibution to AML1/ETO's activity
@en
P2093
P2860
P3181
P1433
P1476
Structural basis for recogniti ...... ibution to AML1/ETO's activity
@en
P2093
Justin Gaudet
Kari Hartman
Liya Roudaia
Nancy A Speck
Rachel C Klet
Thomas M Laue
Tomasz Cierpicki
Yizhou Liu
P2860
P304
P3181
P356
10.1016/J.CCR.2007.04.010
P577
2007-06-01T00:00:00Z