Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1
about
Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpLCooperative interactions at the SLP-76 complex are critical for actin polymerizationSubunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complexSuper-resolution characterization of TCR-dependent signaling clustersHierarchical nanostructure and synergy of multimolecular signalling complexes.The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activationQuantifying intramolecular binding in multivalent interactions: a structure-based synergistic study on Grb2-Sos1 complexRegions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligandsGRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.A peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction.The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.Studies of novel interactions between Nck and VAV SH3 domains.Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selectionc-Cbl-mediated regulation of LAT-nucleated signaling complexesSubcellular dynamics of T cell immunological synapses and kinapses in lymph nodes.Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse.Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions.Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling.A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequencesFunctional implications of plasma membrane condensation for T cell activation.Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activityRecruitment of the adaptor protein Grb2 to EGFR tetramers.T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex.T-cell signaling regulated by the Tec family kinase, Itk.Quantitative in vivo fluorescence cross-correlation analyses highlight the importance of competitive effects in the regulation of protein-protein interactionsModeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.Accounting for photophysical processes and specific signal intensity changes in fluorescence-detected sedimentation velocityAttributes of short linear motifs.Strategies for assessing proton linkage to bimolecular interactions by global analysis of isothermal titration calorimetry dataPhase transitions of multivalent proteins can promote clustering of membrane receptorsThe ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.Shaping the response: the role of FcεRI and Syk expression levels in mast cell signalingMulti-signal sedimentation velocity analysis with mass conservation for determining the stoichiometry of protein complexes.Digital signaling and hysteresis characterize ras activation in lymphoid cells.Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.The boundary structure in the analysis of reversibly interacting systems by sedimentation velocity.Combining biophysical methods for the analysis of protein complex stoichiometry and affinity in SEDPHAT.A quantitative assessment of costimulation and phosphatase activity on microclusters in early T cell signaling.Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
P2860
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P2860
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@ast
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@en
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@en-gb
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@nl
type
label
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@ast
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@en
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@en-gb
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@nl
prefLabel
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@ast
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@en
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@en-gb
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@nl
P2093
P2860
P50
P3181
P356
P1476
Oligomerization of signaling c ...... g of GRB2 to both LAT and SOS1
@en
P2093
Alex Braiman
Brent Bowden
Hiroshi Yamaguchi
Jon C D Houtman
Lawrence E Samelson
P2860
P2888
P304
P3181
P356
10.1038/NSMB1133
P407
P577
2006-09-01T00:00:00Z
P5875
P6179
1034008181