T-cell signaling regulated by the Tec family kinase, Itk. - Test2 - elhamkhani - TriplyDB

T-cell signaling regulated by the Tec family kinase, Itk.

T-cell signaling regulated by the Tec family kinase, Itk.

http://www.wikidata.org/entity/Q33931933

about

Phosphoinositides: tiny lipids with giant impact on cell regulation Expression of the TEL-Syk fusion protein in hematopoietic stem cells leads to rapidly fatal myelofibrosis in mice Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.Regulation of immune responsiveness in vivo by disrupting an early T-cell signaling event using a cell-permeable peptide.In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell Kinase Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs.T-Bet independent development of IFNγ secreting natural T helper 1 cell population in the absence of Itk.The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor ITK tunes IL-4-induced development of innate memory CD8+ T cells in a γδ T and invariant NKT cell-independent manner.ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells.Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase IL-2-inducible T-cell kinase deficiency: clinical presentation and therapeutic approach.Immunodeficiency and immune dysregulation associated with proximal defects of T cell receptor signaling.Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases DNA-methylation profiling distinguishes malignant melanomas from benign nevi.The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection.Itk signals promote neuroinflammation by regulating CD4+ T-cell activation and trafficking.Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue.In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function Alkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytes Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma Immunoreceptor signaling Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression.Simulation of the dynamics of primary immunodeficiencies in CD4+ T-cells.Signal transduction via the T cell antigen receptor in naïve and effector/memory T cells.The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cells Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization.SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch Inherited CD70 deficiency in humans reveals a critical role for the CD70-CD27 pathway in immunity to Epstein-Barr virus infection.

P2860

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P2860

T-cell signaling regulated by the Tec family kinase, Itk.

http://www.wikidata.org/entity/Q33931933

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

T-cell signaling regulated by the Tec family kinase, Itk.

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T-cell signaling regulated by the Tec family kinase, Itk.

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type

label

T-cell signaling regulated by the Tec family kinase, Itk.

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T-cell signaling regulated by the Tec family kinase, Itk.

@en

prefLabel

T-cell signaling regulated by the Tec family kinase, Itk.

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T-cell signaling regulated by the Tec family kinase, Itk.

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CSHPERSPECT.A002287

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Cold Spring Harbor Perspectives in Biology

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T-cell signaling regulated by the Tec family kinase, Itk.

@en

P2093

Amy H Andreotti

http://www.w3.org/2001/XMLSchema#string

Leslie J Berg

http://www.w3.org/2001/XMLSchema#string

Pamela L Schwartzberg

http://www.w3.org/2001/XMLSchema#string

Raji E Joseph

http://www.w3.org/2001/XMLSchema#string

P2860

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk

Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains

Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

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a002287

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scholarly article

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10.1101/CSHPERSPECT.A002287

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7

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2

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2010-06-02T00:00:00Z

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20519342

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2890196

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