IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness
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Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assemblyRegulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamicsStructural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53Structural basis for the actin-binding function of missing-in-metastasisEnlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.A RhoA and Rnd3 cycle regulates actin reassembly during membrane blebbing.Molecular basis for the dual function of Eps8 on actin dynamics: bundling and cappingMechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectorsDynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivoRegulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complexSH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branchesTiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulationThe signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migrationIRSp53 mediates podosome formation via VASP in NIH-Src cells.The neuronal proteins CIPP, Cypin and IRSp53 form a tripartite complex mediated by PDZ and SH3 domains.The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation.The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19.Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2.Dynamin1 is a novel target for IRSp53 protein and works with mammalian enabled (Mena) protein and Eps8 to regulate filopodial dynamics.EPS8 upregulates FOXM1 expression, enhancing cell growth and motilityPathway analysis for genome-wide association study of lung cancer in Han Chinese population.Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.Cell type-specific expression of Eps8 in the mouse hippocampus.Postsynaptic enrichment of Eps8 at dendritic shaft synapses of unipolar brush cells in rat cerebellum.Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages.Hereditary gingival fibromatosis: a systematic review.Identification of HLA‑A*1101‑restricted cytotoxic T lymphocyte epitopes derived from epidermal growth factor pathway substrate number 8.Plasma membrane--cortical cytoskeleton interactions: a cell biology approach with biophysical considerations.Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli.Novel oncoprotein EPS8: a new target for anticancer therapy.BAR domain proteins regulate Rho GTPase signaling.Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation.Differential membrane proteomics using 18O-labeling to identify biomarkers for cholangiocarcinoma.Expression of Eps8 correlates with poor survival in oral squamous cell carcinoma.Src-stimulated IRTKS phosphorylation enhances cell migration.Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasivenessRole for EPS8 in squamous carcinogenesis.Analysis of mutations in the SOS-1 gene in two Polish families with hereditary gingival fibromatosis.
P2860
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P2860
IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness
description
2004 nî lūn-bûn
@nan
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@ast
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@en
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@en-gb
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@nl
type
label
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@ast
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@en
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@en-gb
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@nl
prefLabel
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@ast
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@en
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@en-gb
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@nl
P2093
P1433
P1476
IRSp53/Eps8 complex is importa ...... cer cell motility/invasiveness
@en
P2093
Hiroaki Miki
Naoko Suenaga
Tadaomi Takenawa
Takeshi Terabayashi
Yosuke Funato
P304
P356
10.1158/0008-5472.CAN-04-0327
P407
P577
2004-08-01T00:00:00Z