Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex
about
Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosisA new role for the architecture of microvillar actin bundles in apical retention of membrane proteinsPinkbar is an epithelial-specific BAR domain protein that generates planar membrane structuresRegulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamicsCDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASPWnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8A RhoA and Rnd3 cycle regulates actin reassembly during membrane blebbing.Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells.IRSp53 senses negative membrane curvature and phase separates along membrane tubules.Molecular basis for the dual function of Eps8 on actin dynamics: bundling and cappingEps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF)Propagating cell-membrane waves driven by curved activators of actin polymerizationStructural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli.Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectorsSpermiation: The process of sperm releaseNovel binding partners and differentially regulated phosphorylation sites clarify Eps8 as a multi-functional adaptorRegulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticityRestricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesisSH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branchesInterleukin-1alpha is a regulator of the blood-testis barrierSCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progressionThe signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migrationLoss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in miceThe SH3 domain distinguishes the role of I-BAR proteins IRTKS and MIM in chemotactic response to serumIRSp53 mediates podosome formation via VASP in NIH-Src cells.The BAR Domain Superfamily Proteins from Subcellular Structures to Human DiseasesSH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexesThe Toca-1-N-WASP complex links filopodial formation to endocytosisThe cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19.Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration.Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2.Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.Dynamin1 is a novel target for IRSp53 protein and works with mammalian enabled (Mena) protein and Eps8 to regulate filopodial dynamics.Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cellsDevelopmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells.Severe learning deficits of IRSp53 mutant mice are caused by altered NMDA receptor dependent signal transduction.Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion.
P2860
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P2860
Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex
description
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im Dezember 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/12/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/12/01)
@nl
наукова стаття, опублікована в грудні 2006
@uk
مقالة علمية (نشرت في ديسمبر 2006)
@ar
name
Regulation of cell shape by Cd ...... ity of the Eps8-IRSp53 complex
@ast
Regulation of cell shape by Cd ...... ity of the Eps8-IRSp53 complex
@en
Regulation of cell shape by Cd ...... ity of the Eps8-IRSp53 complex
@nl
type
label
Regulation of cell shape by Cd ...... ity of the Eps8-IRSp53 complex
@ast
Regulation of cell shape by Cd ...... ity of the Eps8-IRSp53 complex
@en
Regulation of cell shape by Cd ...... ity of the Eps8-IRSp53 complex
@nl
prefLabel
Regulation of cell shape by Cd ...... ity of the Eps8-IRSp53 complex
@ast
Regulation of cell shape by Cd ...... ity of the Eps8-IRSp53 complex
@en
Regulation of cell shape by Cd ...... ity of the Eps8-IRSp53 complex
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Regulation of cell shape by Cd ...... ity of the Eps8-IRSp53 complex
@en
P2093
Andrea Ciliberto
Anika Steffen
Hans-Juergen Kreienkamp
Kerstin Berhoerster
Sara Mantoani
Theresia E. B. Stradal
P2860
P2888
P304
P3181
P356
10.1038/NCB1502
P50
P577
2006-12-01T00:00:00Z
P6179
1030719288