LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
about
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicityRac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathwaysA direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylationDysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegansPathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.Models for LRRK2-Linked Parkinsonism.Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activitiesPhosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells.ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression.Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signalingLeucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies.Phosphorylation of LRRK2: from kinase to substrate.New insight into neurodegeneration: the role of proteomics.Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).Interaction of LRRK2 with kinase and GTPase signaling cascadesA proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway.Leucine-rich repeat kinase 2 and Parkinson's disease.UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes.LRRK2 Contributes to Secondary Brain Injury Through a p38/Drosha Signaling Pathway After Traumatic Brain Injury in Rats.A new hypothesis for Parkinson's disease pathogenesis: GTPase-p38 MAPK signaling and autophagy as convergence points of etiology and genomics
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LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
description
2010 nî lūn-bûn
@nan
2010 թուականին հրատարակուած գիտական յօդուած
@hyw
2010 թվականին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@ast
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@en
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@en-gb
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@nl
type
label
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@ast
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@en
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@en-gb
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@nl
prefLabel
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@ast
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@en
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@en-gb
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@nl
P2093
P2860
P921
P356
P1476
LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins
@en
P2093
P2860
P356
10.1159/000285509
P407
P577
2010-01-01T00:00:00Z