Identification of a primary target of thalidomide teratogenicity
about
Apigenin sensitizes prostate cancer cells to Apo2L/TRAIL by targeting adenine nucleotide translocase-2Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomidePomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitroWhat is the functional role of the thalidomide binding protein cereblon?A comprehensive review of lenalidomide in B-cell non-Hodgkin lymphomaGenetic Syndromes, Maternal Diseases and Antenatal Factors Associated with Autism Spectrum Disorders (ASD)Strategically targeting MYC in cancerDrugging the undruggables: exploring the ubiquitin system for drug developmentNovel strategies to target the ubiquitin proteasome system in multiple myelomaRegulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin LigasesQuantifying ubiquitin signalingCurrent perspectives on the use of alternative species in human health and ecological hazard assessmentsUse of lenalidomide in the management of relapsed or refractory multiple myeloma: expert recommendations in KoreaMultiple myeloma: 2014 Update on diagnosis, risk-stratification, and managementNew drugs and novel mechanisms of action in multiple myeloma in 2013: a report from the International Myeloma Working Group (IMWG)Evolving Paradigms in the Management of Multiple Myeloma: Novel Agents and Targeted TherapiesBuilding and remodelling Cullin-RING E3 ubiquitin ligasesStructure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomideDrug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms.Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligaseCullin-RING ubiquitin E3 ligase regulation by the COP9 signalosomeA novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligaseSystematic approaches to identify E3 ligase substratesThalidomide-induced teratogenesis: history and mechanismsDistinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BA trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitinsThe myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteinsLenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cellsMechanisms mediating environmental chemical-induced endocrine disruption in the adrenal glandIdentification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol AIdentification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugsImmunomodulatory effects in a phase II study of lenalidomide combined with cetuximab in refractory KRAS-mutant metastatic colorectal cancer patientsThe thalidomide-binding domain of cereblon defines the CULT domain family and is a new member of the β-tent foldA novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclastsExploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphomaChemical metabolic inhibitors for the treatment of blood-borne cancersDRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradationPrediction of developmental chemical toxicity based on gene networks of human embryonic stem cellsCRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis.Exploiting large-scale drug-protein interaction information for computational drug repurposing.
P2860
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P2860
Identification of a primary target of thalidomide teratogenicity
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Identification of a primary target of thalidomide teratogenicity
@ast
Identification of a primary target of thalidomide teratogenicity
@en
Identification of a primary target of thalidomide teratogenicity
@en-gb
Identification of a primary target of thalidomide teratogenicity
@nl
type
label
Identification of a primary target of thalidomide teratogenicity
@ast
Identification of a primary target of thalidomide teratogenicity
@en
Identification of a primary target of thalidomide teratogenicity
@en-gb
Identification of a primary target of thalidomide teratogenicity
@nl
prefLabel
Identification of a primary target of thalidomide teratogenicity
@ast
Identification of a primary target of thalidomide teratogenicity
@en
Identification of a primary target of thalidomide teratogenicity
@en-gb
Identification of a primary target of thalidomide teratogenicity
@nl
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P1476
Identification of a primary target of thalidomide teratogenicity
@en
P2093
Hideki Ando
Hiroshi Handa
Kentaro Hotta
Takayuki Suzuki
Takumi Ito
Toshihiko Ogura
Yoshimasa Imamura
Yuki Yamaguchi
P2860
P304
P3181
P356
10.1126/SCIENCE.1177319
P407
P577
2010-03-12T00:00:00Z