Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation
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Identification of a primary target of thalidomide teratogenicityPomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitroBalance of the Sexes: Addressing Sex Differences in Preclinical ResearchAn Update on the Pathogenesis of OsteochondrosisVascular anomalies: from genetics toward models for therapeutic trialsThalidomide-induced teratogenesis: history and mechanismsTranscriptomic characterization of C57BL/6 mouse embryonic stem cell differentiation and its modulation by developmental toxicantsApplication of synthetic photostable retinoids induces novel limb and facial phenotypes during chick embryogenesis in vivoThe functional therapeutic chemical classification systemPrevalence of congenital limb defects: Data from birth defects registries in three provinces in Southern Thailand.A HAND to TBX5 Explains the Link Between Thalidomide and Cardiac Diseases.Thalidomide-a notorious sedative to a wonder anticancer drug.Environmental impact on vascular development predicted by high-throughput screening.Thalidomide: the tragedy of birth defects and the effective treatment of disease.Teratogenic effects of thalidomide: molecular mechanisms.A case report of a patient with hereditary hemorrhagic telangiectasia treated successively with thalidomide and bevacizumabPrevention of neural tube defects: a cross-sectional study of the uptake of folic acid supplementation in nearly half a million womenDeletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.Tetra-phocomelia: the seal limb deformity - a case report.Phocomelia: a worldwide descriptive epidemiologic study in a large series of cases from the International Clearinghouse for Birth Defects Surveillance and Research, and overview of the literatureTreatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of MedicineA transgenic, mesodermal specific, Dkk1 mouse model recapitulates a spectrum of human congenital limb reduction defects.In vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems.Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues.Improving the Pipeline for Developing and Testing Pharmacological Treatments in Pregnancy.Nitric oxide rescues thalidomide mediated teratogenicity.Applying evolutionary genetics to developmental toxicology and risk assessment.New Findings in eNOS gene and Thalidomide Embryopathy Suggest pre-transcriptional effect variants as susceptibility factors.HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide.In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon.Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model.Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular β-catenin organization and signaling in AER during mouse limb developmentA reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterning.Disruption of embryonic vascular development in predictive toxicology.Deciphering the mystery of thalidomide teratogenicity.Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma.Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy.The molecular basis of human congenital limb malformations.Pericytes as targets in hereditary hemorrhagic telangiectasia.In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.
P2860
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P2860
Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Thalidomide induces limb defec ...... th during early limb formation
@ast
Thalidomide induces limb defec ...... th during early limb formation
@en
Thalidomide induces limb defec ...... th during early limb formation
@nl
type
label
Thalidomide induces limb defec ...... th during early limb formation
@ast
Thalidomide induces limb defec ...... th during early limb formation
@en
Thalidomide induces limb defec ...... th during early limb formation
@nl
prefLabel
Thalidomide induces limb defec ...... th during early limb formation
@ast
Thalidomide induces limb defec ...... th during early limb formation
@en
Thalidomide induces limb defec ...... th during early limb formation
@nl
P2093
P2860
P3181
P356
P1476
Thalidomide induces limb defec ...... th during early limb formation
@en
P2093
Christina Therapontos
Erin R Gardner
William D Figg
P2860
P304
P3181
P356
10.1073/PNAS.0901505106
P407
P577
2009-05-26T00:00:00Z