Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation - Test2 - elhamkhani - TriplyDB

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

http://www.wikidata.org/entity/Q24653215

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Identification of a primary target of thalidomide teratogenicity Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro Balance of the Sexes: Addressing Sex Differences in Preclinical Research An Update on the Pathogenesis of Osteochondrosis Vascular anomalies: from genetics toward models for therapeutic trials Thalidomide-induced teratogenesis: history and mechanisms Transcriptomic characterization of C57BL/6 mouse embryonic stem cell differentiation and its modulation by developmental toxicants Application of synthetic photostable retinoids induces novel limb and facial phenotypes during chick embryogenesis in vivo The functional therapeutic chemical classification system Prevalence of congenital limb defects: Data from birth defects registries in three provinces in Southern Thailand.A HAND to TBX5 Explains the Link Between Thalidomide and Cardiac Diseases.Thalidomide-a notorious sedative to a wonder anticancer drug.Environmental impact on vascular development predicted by high-throughput screening.Thalidomide: the tragedy of birth defects and the effective treatment of disease.Teratogenic effects of thalidomide: molecular mechanisms.A case report of a patient with hereditary hemorrhagic telangiectasia treated successively with thalidomide and bevacizumab Prevention of neural tube defects: a cross-sectional study of the uptake of folic acid supplementation in nearly half a million women Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.Tetra-phocomelia: the seal limb deformity - a case report.Phocomelia: a worldwide descriptive epidemiologic study in a large series of cases from the International Clearinghouse for Birth Defects Surveillance and Research, and overview of the literature Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine A transgenic, mesodermal specific, Dkk1 mouse model recapitulates a spectrum of human congenital limb reduction defects.In vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems.Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues.Improving the Pipeline for Developing and Testing Pharmacological Treatments in Pregnancy.Nitric oxide rescues thalidomide mediated teratogenicity.Applying evolutionary genetics to developmental toxicology and risk assessment.New Findings in eNOS gene and Thalidomide Embryopathy Suggest pre-transcriptional effect variants as susceptibility factors.HIF-1α and HIF-2α induced angiogenesis in gastrointestinal vascular malformation and reversed by thalidomide.In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon.Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model.Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular β-catenin organization and signaling in AER during mouse limb development A reevaluation of X-irradiation-induced phocomelia and proximodistal limb patterning.Disruption of embryonic vascular development in predictive toxicology.Deciphering the mystery of thalidomide teratogenicity.Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma.Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy.The molecular basis of human congenital limb malformations.Pericytes as targets in hereditary hemorrhagic telangiectasia.In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

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Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation

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2009 թվականի մայիսին հրատարակված գիտական հոդված

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2009年の論文

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Thalidomide induces limb defec ...... th during early limb formation

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Thalidomide induces limb defec ...... th during early limb formation

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Thalidomide induces limb defec ...... th during early limb formation

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Thalidomide induces limb defec ...... th during early limb formation

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Thalidomide induces limb defec ...... th during early limb formation

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Thalidomide induces limb defec ...... th during early limb formation

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Thalidomide induces limb defec ...... th during early limb formation

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Thalidomide induces limb defec ...... th during early limb formation

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Thalidomide induces limb defec ...... th during early limb formation

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Christina Therapontos

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Erin R Gardner

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William D Figg

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P2860

Thalidomide is an inhibitor of angiogenesis

Defects and disabilities of thalidomide children

Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning

A series of normal stages in the development of the chick embryo

A series of normal stages in the development of the chick embryo

In vivo imaging of embryonic vascular development using transgenic zebrafish

Thalidomide attenuates nitric oxide mediated angiogenesis by blocking migration of endothelial cells

Recognition of thalidomide defects.

Hypothesis: thalidomide embryopathy-proposed mechanism of action.

Mechanism of action in thalidomide teratogenesis.

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