Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein
about
The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth.Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodesIntegrin signalling and function in immune cells.SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion
P2860
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P2860
Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Regulation and function of SKA ...... tion-promoting adaptor protein
@ast
Regulation and function of SKA ...... tion-promoting adaptor protein
@en
Regulation and function of SKA ...... tion-promoting adaptor protein
@nl
type
label
Regulation and function of SKA ...... tion-promoting adaptor protein
@ast
Regulation and function of SKA ...... tion-promoting adaptor protein
@en
Regulation and function of SKA ...... tion-promoting adaptor protein
@nl
prefLabel
Regulation and function of SKA ...... tion-promoting adaptor protein
@ast
Regulation and function of SKA ...... tion-promoting adaptor protein
@en
Regulation and function of SKA ...... tion-promoting adaptor protein
@nl
P2093
P2860
P356
P1476
Regulation and function of SKA ...... tion-promoting adaptor protein
@en
P2093
Christopher E Rudd
P2860
P304
P356
10.1074/JBC.M508774200
P407
P577
2006-05-12T00:00:00Z