Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion
about
PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular SwitchARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated AdhesionThe N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptorsLRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.Essential gene profiles in breast, pancreatic, and ovarian cancer cells.Adapters in the organization of mast cell signaling.The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodesThe ins and outs of leukocyte integrin signaling.Integrin signalling and function in immune cells.SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.Integrin Activation Through the Hematopoietic Adapter Molecule ADAP Regulates Dendritic Development of Hippocampal Neurons.Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling.SKAP1 is dispensable for chemokine-induced migration of primary T-cellsLFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formationCD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft CellsNon-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1.T-cell immune adaptor SKAP1 regulates the induction of collagen-induced arthritis in mice.Ubc9 Binds to ADAP and Is Required for Rap1 Membrane Recruitment, Rac1 Activation, and Integrin-Mediated T Cell Adhesion.The Role of Mst1 in Lymphocyte Homeostasis and Function.
P2860
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P2860
Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Functional defects of SKAP-55- ...... the adaptor in LFA-1 adhesion
@en
type
label
Functional defects of SKAP-55- ...... the adaptor in LFA-1 adhesion
@en
prefLabel
Functional defects of SKAP-55- ...... the adaptor in LFA-1 adhesion
@en
P2093
P2860
P356
P1476
Functional defects of SKAP-55- ...... the adaptor in LFA-1 adhesion
@en
P2093
Christopher E Rudd
Hongyan Wang
Matt Lovatt
P2860
P304
P356
10.1128/MCB.00556-07
P407
P577
2007-07-23T00:00:00Z