Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS
about
Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific bindingMolecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1Molecular basis for negative regulation of the glucagon receptorLandmark studies on the glucagon subfamily of GPCRs: from small molecule modulators to a crystal structureStructure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptorsCrystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domainCrystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 ReceptorCrystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled ReceptorsTransmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsConformational states of the full-length glucagon receptorAgnathan VIP, PACAP and their receptors: ancestral origins of today's highly diversified formsHomology modeling and molecular docking of human pituitary adenylate cyclase‑activating polypeptide I receptor.Molecular basis of glucagon-like peptide 1 docking to its intact receptor studied with carboxyl-terminal photolabile probesThe vasoactive intestinal peptide (VIP) alpha-Helix up to C terminus interacts with the N-terminal ectodomain of the human VIP/Pituitary adenylate cyclase-activating peptide 1 receptor: photoaffinity, molecular modeling, and dynamicsSecretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Spatial approximations between residues 6 and 12 in the amino-terminal region of glucagon-like peptide 1 and its receptor: a region critical for biological activity.Elucidation of the active conformation of the amino terminus of receptor-bound secretin using intramolecular disulfide bond constraints.Mutational and cysteine scanning analysis of the glucagon receptor N-terminal domain.Insights into the structure of class B GPCRs.Importance of each residue within secretin for receptor binding and biological activityVIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies.Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling.Biophysical characterization of G-protein coupled receptor-peptide ligand binding.Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophorePituitary adenylate cyclase activating polypeptide (PACAP) signalling exerts chondrogenesis promoting and protecting effects: implication of calcineurin as a downstream target.Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis.International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.A structure-function study of PACAP using conformationally restricted analogs: Identification of PAC1 receptor-selective PACAP agonistsStructure-Activity Relationship Studies of N- and C-Terminally Modified Secretin Analogs for the Human Secretin ReceptorPharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1.Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor.Consequences of splice variation on Secretin family G protein-coupled receptor functionThe VPAC1 receptor: structure and function of a class B GPCR prototype.Structural and molecular conservation of glucagon-like Peptide-1 and its receptor confers selective ligand-receptor interaction.Insights into the structural basis of endogenous agonist activation of family B G protein-coupled receptorsFunctional Pairing of Class B1 Ligand-GPCR in Cephalochordate Provides Evidence of the Origin of PTH and PACAP/Glucagon Receptor Family.Effects of pH and temperature on photoaffinity labeling of Family B G protein-coupled receptors.Exploration of the endogenous agonist mechanism for activation of secretin and VPAC1 receptors using synthetic glycosylated peptides
P2860
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P2860
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@ast
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@en
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@en-gb
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@nl
type
label
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@ast
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@en
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@en-gb
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@nl
prefLabel
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@ast
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@en
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@en-gb
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@nl
P2093
P2860
P356
P1476
Solution structure and mutatio ...... xtracellular domain of PAC1-RS
@en
P2093
Ana Pereda-Lopez
Chaohong Sun
Danying Song
Edward T Olejniczak
Karl A Walter
Larry R Solomon
Leo W Barrett
Marc R Lake
Marie E Uchic
Paul L Richardson
P2860
P304
P356
10.1073/PNAS.0611397104
P407
P577
2007-05-08T00:00:00Z