Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3
about
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2bSPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 productionRegulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2bA protease-independent function for SPPL3 in NFAT activationSubstrate requirements for SPPL2b-dependent regulated intramembrane proteolysisAge and diet affect gene expression profile in canine skeletal muscleCore protein of pestiviruses is processed at the C terminus by signal peptide peptidase.Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3Plasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesisProteomic Substrate Identification for Membrane Proteases in the BrainAssembly, trafficking and function of gamma-secretaseAn internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain proteinThe PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysisDifferential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase InhibitorsCellular functions of gamma-secretase-related proteins.Genetic determinants of hyaloid and retinal vasculature in zebrafish.Signal peptide peptidase and its homologs in Arabidopsis thaliana--plant tissue-specific expression and distinct subcellular localization.A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity.γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide PeptidaseRegulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease.Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic designExperimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana.Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylationThree-dimensional structure of the signal peptide peptidaseProteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving ProteasesIntramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivoZebrafish as a model to understand autophagy and its role in neurological disease.Intramembrane proteolysis in regulated protein trafficking.Hydroxyproline-based DNA mimics provide an efficient gene silencing in vitro and in vivo.Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's diseaseSignal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes.Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.The signal peptide peptidase is required for pollen function in Arabidopsis.
P2860
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P2860
Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
name
Differential localization and ...... in homologues SPPL2b and SPPL3
@ast
Differential localization and ...... in homologues SPPL2b and SPPL3
@en
Differential localization and ...... in homologues SPPL2b and SPPL3
@en-gb
Differential localization and ...... in homologues SPPL2b and SPPL3
@nl
type
label
Differential localization and ...... in homologues SPPL2b and SPPL3
@ast
Differential localization and ...... in homologues SPPL2b and SPPL3
@en
Differential localization and ...... in homologues SPPL2b and SPPL3
@en-gb
Differential localization and ...... in homologues SPPL2b and SPPL3
@nl
prefLabel
Differential localization and ...... in homologues SPPL2b and SPPL3
@ast
Differential localization and ...... in homologues SPPL2b and SPPL3
@en
Differential localization and ...... in homologues SPPL2b and SPPL3
@en-gb
Differential localization and ...... in homologues SPPL2b and SPPL3
@nl
P2093
P50
P921
P3181
P356
P1476
Differential localization and ...... in homologues SPPL2b and SPPL3
@en
P2093
Bettina Schmid
Christof Haffner
Harald Steiner
P304
P3181
P356
10.1074/JBC.M501645200
P407
P577
2005-11-25T00:00:00Z