about
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2bRegulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2bThe α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b)Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysisThe transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2bFoamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylationA Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases.Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cellsSubstrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74.Latest emerging functions of SPP/SPPL intramembrane proteases.Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving ProteasesSignal peptide peptidases and gamma-secretase: cousins of the same protease family?Intramembrane proteolysis by gamma-secretase.Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivoMechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases.Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteinsSignal peptide peptidase and SPP-like proteases - Possible therapeutic targets?The Nicastrin ectodomain adopts a highly thermostable structure.Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.A non-amyloidogenic function of BACE-2 in the secretory pathway.Apical sorting of beta-secretase limits amyloid beta-peptide production.The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process.Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling.The intramembrane protease SPPL2A is critical for tooth enamel formation.CLN5 is cleaved by members of the SPP/SPPL family to produce a mature soluble protein.Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteinsProteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developmentsSignal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteinsThe intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholambanSignal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Regina Fluhrer
@ast
Regina Fluhrer
@en
Regina Fluhrer
@es
Regina Fluhrer
@nl
type
label
Regina Fluhrer
@ast
Regina Fluhrer
@en
Regina Fluhrer
@es
Regina Fluhrer
@nl
prefLabel
Regina Fluhrer
@ast
Regina Fluhrer
@en
Regina Fluhrer
@es
Regina Fluhrer
@nl
P214
P106
P214
P31
P496
0000-0002-9778-4643
P7859
viaf-57666823