Small-molecule inhibition of APT1 affects Ras localization and signaling
about
Palmitoylated calnexin is a key component of the ribosome-translocon complex.Global profiling of dynamic protein palmitoylationThe physiology of protein S-acylation2-Bromopalmitate reduces protein deacylation by inhibition of acyl-protein thioesterase enzymatic activitiesProtein Depalmitoylation Is Induced by Wnt5a and Promotes Polarized Cell Behavior.Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterasesLarge Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates CatalysisStereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategyOmuralide and vibralactone: differences in the proteasome- β-lactone-γ-lactam binding scaffold alter target preferencesBiochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A)Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated ProteinsQuantitative control of protein S-palmitoylation regulates meiotic entry in fission yeastThe palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domainDistinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channelsSignaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular locationZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarityTargeting protein lipidation in diseaseRaft protein clustering alters N-Ras membrane interactions and activation pattern.Individual S-acylated cysteines differentially contribute to H-Ras endomembrane trafficking and acylation/deacylation cycles.Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events.Phospholipase A/Acyltransferase enzyme activity of H-rev107 inhibits the H-RAS signaling pathwayPalmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis.Ion channel regulation by protein S-acylation.Dynamic palmitoylation and the role of DHHC proteins in T cell activation and anergy.Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis.Crystal structure of Pelagibacterium halotolerans PE8: New insight into its substrate-binding patternRecent trends and observations in the design of high-quality screening collections.Biology-oriented synthesis.Spatial cycles in G-protein crowd controlSite-specific analysis of protein S-acylation by resin-assisted captureChemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery.Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti Trypanosoma brucei agent.Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probesBoron-based inhibitors of acyl protein thioesterases 1 and 2.A systematic analysis of protein palmitoylation in Caenorhabditis elegansPalmitoylation and depalmitoylation dynamics at a glance.The intracellular dynamic of protein palmitoylationIdentification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2)Target identification for small bioactive molecules: finding the needle in the haystack.
P2860
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P2860
Small-molecule inhibition of APT1 affects Ras localization and signaling
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Small-molecule inhibition of APT1 affects Ras localization and signaling
@ast
Small-molecule inhibition of APT1 affects Ras localization and signaling
@en
Small-molecule inhibition of APT1 affects Ras localization and signaling
@en-gb
Small-molecule inhibition of APT1 affects Ras localization and signaling
@nl
type
label
Small-molecule inhibition of APT1 affects Ras localization and signaling
@ast
Small-molecule inhibition of APT1 affects Ras localization and signaling
@en
Small-molecule inhibition of APT1 affects Ras localization and signaling
@en-gb
Small-molecule inhibition of APT1 affects Ras localization and signaling
@nl
prefLabel
Small-molecule inhibition of APT1 affects Ras localization and signaling
@ast
Small-molecule inhibition of APT1 affects Ras localization and signaling
@en
Small-molecule inhibition of APT1 affects Ras localization and signaling
@en-gb
Small-molecule inhibition of APT1 affects Ras localization and signaling
@nl
P2093
P50
P3181
P356
P1476
Small-molecule inhibition of APT1 affects Ras localization and signaling
@en
P2093
Beate Schölermann
Christian Hedberg
Geoffrey W Coates
John W Kramer
Marc Gerauer
Marion Rusch
Nachiket Vartak
Oliver Rocks
Philippe I H Bastiaens
Sascha Menninger
P2888
P304
P3181
P356
10.1038/NCHEMBIO.362
P407
P577
2010-06-01T00:00:00Z
P5875
P6179
1012204629