about
Capturing Biological Activity in Natural Product Fragments by Chemical SynthesisDiversity-oriented synthetic strategies applied to cancer chemical biology and drug discoveryNatural-product-derived fragments for fragment-based ligand discoveryNeuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4Highly stereoselective synthesis of natural-product-like hybrids by an organocatalytic/multicomponent reaction sequence.Probing chemical space with alkaloid-inspired libraries.Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversificationDiversity-oriented synthesis: producing chemical tools for dissecting biology.Natural products: a continuing source of novel drug leadsChemistry-based functional proteomics for drug target deconvolution.Target identification for small bioactive molecules: finding the needle in the haystack.Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors.Druggable chemical space and enumerative combinatorics.From a multipotent stilbene to soluble epoxide hydrolase inhibitors with antiproliferative properties.[Small compounds libraries: a research tool for chemical biology].Discovery of neuritogenic compound classes inspired by natural products.A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway.Catalytic enantioselective 1,3-dipolar cycloadditions of azomethine ylides for biology-oriented synthesis.Diversity-oriented synthesis of drug-like macrocyclic scaffolds using an orthogonal organo- and metal catalysis strategy.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library.A Tryptoline Ring-Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine.A unifying review of bioassay-guided fractionation, effect-directed analysis and related techniques.Tetrahydroisoquinolines: New Inhibitors of Neutrophil Extracellular Trap (NET) Formation.Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures.Clustered distribution of natural product leads of drugs in the chemical space as influenced by the privileged target-sites.A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds.From micrograms to grams: scale-up synthesis of eribulin mesylate.Amorfrutins: A promising class of natural products that are beneficial to health.Design and synthesis of analogues of natural products.Dereplication: racing to speed up the natural products discovery process."Pruning of biomolecules and natural products (PBNP)": an innovative paradigm in drug discovery.Nature-inspired stereospecific total synthesis of P-(+)-dispegatrine and four other monomeric sarpagine indole alkaloids.Enantioselective Organocatalytic Synthesis of a Secoyohimbane-Inspired Compound Collection with Neuritogenic Activity.Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery.(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.Discovery of inhibitors of the Wnt and Hedgehog signaling pathways through the catalytic enantioselective synthesis of an iridoid-inspired compound collection.Biology-oriented synthesis of a tetrahydroisoquinoline-based compound collection targeting microtubule polymerization.
P2860
Q26772873-8420EB21-E73E-4E26-BD7D-5621A1D89D4CQ26829081-F3C21DFE-B21A-4BB4-B16B-3B7FA41426C4Q27683610-995B7DBF-E60A-4546-97D1-A275A450584DQ27700248-187B99AE-544F-463A-B8F9-993B432AC1C8Q30316563-0B77D228-9D5E-411C-AA52-DD81E0B9B015Q33626989-E3AE4F44-DA27-4B56-B8FF-7BC75A98F155Q34002570-2E29931C-F722-45DA-A884-869CADB852B3Q34207033-FB9DE362-76E4-4237-B55C-14ECFA248310Q34227440-10CC6659-C9DA-46B0-ABAD-34EC97AE9976Q34328933-99318AD1-11B8-4474-BBC3-8A3F83177C28Q34342905-6AB87343-E9FF-4862-BC10-5577921CBDAEQ34589404-B3132596-1023-40F9-8228-2357B32C286AQ34660121-10B68586-FFC7-4743-AE74-7A8C6EF38AACQ34675477-248295B2-02A9-424B-BA3C-B7761A734129Q34675957-81C18EDF-A621-44E9-901B-F4B153592DA7Q34733011-381D8AF4-FCEE-462B-9A43-B7563CA4FDEFQ34754759-7015F7CF-E3C6-4463-9D99-45CFFB7EBA05Q34993742-275873A6-AC26-4447-94D1-0ACB45CF565BQ35050064-46E496C4-92AF-4B6E-B976-282068028807Q35147243-4C0D8344-AE52-4D3A-AB29-493065906277Q35278303-2A822252-14FF-418F-81B9-3E1D2110B8E9Q35738960-5EFB3054-B2CE-4332-B5AF-F35BE5E98A19Q36172912-90FADB67-E756-4E89-9324-E67440C621CDQ36207545-626C08F2-997F-48BC-88D6-C436CD7465C5Q36239113-3F6B19CB-DDF5-4CA4-B76A-9433CC1B87FFQ36291317-FA83B072-EE9B-4F00-A7A9-70A2B1571951Q36372691-9331541F-2483-442F-9B25-B96B4C469B56Q37737158-32597B21-6C6C-40D2-A7C9-220A35FDB330Q38074314-BAA14D38-7D7E-4B34-9104-F8FD1520F1C9Q38125086-3DAA6A1E-FAEE-46BC-A347-6735A6CA3F6BQ38217801-CAF8A828-6756-498D-8800-040029717714Q38398596-06125B4B-5971-4356-9847-4D5CAC0828A4Q38409890-65FD5AA8-9D61-493D-9F88-0158935591F0Q38475630-831F562B-44E5-4C06-859F-EC5B21761EEEQ38563288-D1E07323-4A32-4212-8C3F-FBDE52BF018EQ38706972-396DD860-9EB2-40BA-8D4D-926A0F1A3217Q38836332-76C6AB43-1509-47AE-8F2C-AAFE5434E7A4Q38906824-E90E657A-F990-4974-A25C-68311CC33AD8Q39081836-55FDBBAB-81D2-4B30-92B2-72F4E89F93FEQ39201808-105B5078-0D19-4470-9EEA-C2A052B0FA94
P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Biology-oriented synthesis.
@ast
Biology-oriented synthesis.
@en
Biology-oriented synthesis.
@en-gb
Biology-oriented synthesis.
@nl
type
label
Biology-oriented synthesis.
@ast
Biology-oriented synthesis.
@en
Biology-oriented synthesis.
@en-gb
Biology-oriented synthesis.
@nl
prefLabel
Biology-oriented synthesis.
@ast
Biology-oriented synthesis.
@en
Biology-oriented synthesis.
@en-gb
Biology-oriented synthesis.
@nl
P2860
P50
P356
P1476
Biology-oriented synthesis.
@en
P2093
Stefan Wetzel
P2860
P304
10800-10826
P356
10.1002/ANIE.201007004
P407
P577
2011-10-28T00:00:00Z