Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia
about
Down-regulation of Hox A7 is required for cell adhesion and migration on fibronectin during early HL-60 monocytic differentiationHOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cellsDifferential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1MicroRNA-196: critical roles and clinical applications in development and cancerAbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteinsConstitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemiaDistinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosminRetroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cellsHematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2Altered HOX and WNT7A expression in human lung cancerExpression of a CALM-AF10 fusion gene leads to Hoxa cluster overexpression and acute leukemia in transgenic miceCorrelation of expression of BP1, a homeobox gene, with estrogen receptor status in breast cancerAmegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutationTyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell linesAbsence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndromeHuman HOX gene mutationsThe chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cellsHOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferationSurvival regulation of leukemia stem cellsHigh levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming eventA new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemiasEvidence that the Pim1 kinase gene is a direct target of HOXA9Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteinsModulating Hox gene functions during animal body patterningp21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells.HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.Classifying leukemia types with chromatin conformation data.Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes.Molecular and transcriptional regulation of megakaryocyte differentiation.Molecular control of megakaryopoiesis and thrombopoiesis.The molecular basis of congenital thrombocytopenias: insights into megakaryopoiesis.Hoxa10 null animals exhibit reduced platelet biogenesis.Chromatin conformation signatures of cellular differentiationIntegrative meta-analysis of differential gene expression in acute myeloid leukemiaGene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma.ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.Ectopic expression of HOXC6 blocks myeloid differentiation and predisposes to malignant transformation.Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.
P2860
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P2860
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@ast
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@en
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@en-gb
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@nl
type
label
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@ast
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@en
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@en-gb
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@nl
prefLabel
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@ast
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@en
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@en-gb
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@nl
P2093
P2860
P921
P3181
P356
P1476
Overexpression of HOXA10 in mu ...... eads to acute myeloid leukemia
@en
P2093
G Sauvageau
H J Lawrence
P M Lansdorp
R K Humphries
U Thorsteinsdottir
W Dragowska
P2860
P304
P3181
P356
10.1128/MCB.17.1.495
P407
P577
1997-01-01T00:00:00Z