Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia - Test2 - elhamkhani - TriplyDB

Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

http://www.wikidata.org/entity/Q28273406

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A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96 Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1 Evi27 encodes a novel membrane protein with homology to the IL17 receptor Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia Cloning and expression of a new HOXC6 transcript encoding a repressing protein Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1 Identification and characterization of Hoxa9 binding sites in hematopoietic cells AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation Nup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p.The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities TALE homeoproteins as HOX11-interacting partners in T-cell leukemia Human HOX gene mutations The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9 A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1 Survival regulation of leukemia stem cells The role of NUP98 gene fusions in hematologic malignancy High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event The HoxB1 hexapeptide is a prefolded domain: implications for the Pbx1/Hox interaction Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins Hematopoietic, angiogenic and eye defects in Meis1 mutant animals.Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation.Imaging hematopoietic precursor division in real time.Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes.Dissection of the transformation of primary human hematopoietic cells by the oncogene NUP98-HOXA9 The peripheral cannabinoid receptor, Cb2, in retrovirally-induced leukemic transformation and normal hematopoiesis.Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2.High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia.Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusions HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

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Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

http://www.wikidata.org/entity/Q28273406

description

1996 nî lūn-bûn

@nan

1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի փետրվարին հրատարակված գիտական հոդված

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1996年の論文

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1996年学术文章

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1996年学术文章

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1996年学术文章

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1996年学术文章

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1996年學術文章

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name

Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia

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Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia

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Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia

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type

label

Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia

@ast

Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia

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Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia

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prefLabel

Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia

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Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia

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Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia

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Nature Genetics

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Fusion of the nucleoporin gene ...... 15) in human myeloid leukaemia

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C L Willman

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M P Lee

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N A Jenkins

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The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA

Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene

Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif.

Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment

Identification of protein coding regions by database similarity search

The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes

Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression

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Two additional cases of acute myeloid leukemia with t(7;11)(p15;p15) having low neutrophil alkaline phosphatase scores.

An integrated physical map of 210 markers assigned to the short arm of human chromosome 11.

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10.1038/NG0296-154

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12

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14636280

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