Evidence for allosteric interactions of antagonist binding to the smoothened receptor
about
Structure of the human smoothened receptor bound to an antitumour agentStructure and function of the Smoothened extracellular domain in vertebrate Hedgehog signalingStructural basis for Smoothened receptor modulation and chemoresistance to anticancer drugsSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicineMedicinal history of North American Veratrum.Endocannabinoids are conserved inhibitors of the Hedgehog pathway.Sonic Hedgehog Signaling: Evidence for Its Protective Role in Endotoxin Induced Acute Lung Injury in Mouse ModelHedgehog pathway as a drug target: Smoothened inhibitors in development.Hedgehog controls hepatic stellate cell fate by regulating metabolismPTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young miceAutologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson's disease model.Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication.Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathwaysHedgehog pathway inhibitors: a patent review (2009--present).Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies.Regulation of the oncoprotein Smoothened by small molecules.Synthesis and cytotoxicity studies of Hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents.The development of a high-content screening binding assay for the smoothened receptor.Oxysterols are allosteric activators of the oncoprotein Smoothened.Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.The cell adhesion molecule CHL1 interacts with patched-1 to regulate apoptosis during postnatal cerebellar development.
P2860
Q27677951-2049BE60-C59D-4507-844C-F232C5A99389Q27680483-93E60FBA-F9E5-42AD-A606-0C7C6C8C4B7EQ27684635-16081FB0-8522-4D9C-A7DD-F5FC1345D29EQ33890786-2D857D70-05E2-460E-9EE0-86AF96DB59DCQ33927093-29A7FE0D-98DE-4266-BB1A-C6B6590D1990Q34441529-DEA82F32-5A39-4B59-AD58-FCD6CD253FABQ35212749-378FBE52-C4CA-4230-BFB9-24D49B0C310CQ35834407-E71D254A-09A4-410B-B97B-B862646410B0Q35885181-6E267053-065E-4E52-AA94-1810658E4086Q36345406-250C923A-258C-49C2-BA0E-368228814ABFQ36622772-C1847E7A-2FC0-4F98-B377-6B40DCC061A5Q36882491-6F98018C-1898-4C5A-84AD-93914B24B3EEQ36914809-E88C964B-1A64-44D4-BA7D-2CF7CAD80C15Q37306391-E4F5C6C8-C9E7-4738-AEF4-E6524E616A96Q38072095-963F9CEC-D115-4448-9753-2DF45430FF00Q38213666-0164FD36-275E-45FC-AB0A-1388F404C925Q38382683-C9397FC7-0A8F-4AB9-A8E3-FDDDEA1AD1CCQ39024542-C20EE65C-653C-4A10-8DF8-0F63EA89E4A9Q39340516-3D441AAA-4D88-4AAA-AC33-440367F76168Q40530687-BC4EADD6-11F0-4D49-86C1-F1CE34FAE043Q42001900-7D0881EB-FADB-4B5C-94E4-F7960A6371E3Q48255626-0C0B2BD3-A6AB-49A1-9B37-0A3C9C8FA1A2
P2860
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@ast
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@en
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@en-gb
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@nl
type
label
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@ast
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@en
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@en-gb
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@nl
prefLabel
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@ast
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@en
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@en-gb
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@nl
P2093
P3181
P356
P1476
Evidence for allosteric interactions of antagonist binding to the smoothened receptor
@en
P2093
Aidan Gilmartin
Brandon Turunen
Cynthia M Rominger
David H Rominger
Elizabeth A Davenport
Keith R Hornberger
Kenneth Lawrie
Lorena A Kallal
Lynette McMillan
Maggie Truong
P304
P3181
P356
10.1124/JPET.109.152090
P407
P577
2009-06-01T00:00:00Z