Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling - Test2 - elhamkhani - TriplyDB

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

http://www.wikidata.org/entity/Q27680483

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Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1 Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Structural basis of Smoothened regulation by its extracellular domains A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation Prediction of G Protein-Coupled Receptors with SVM-Prot Features and Random Forest Smoothened goes molecular: new pieces in the hedgehog signaling puzzle Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi.Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand Smoothened Regulation: A Tale of Two Signals.Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail.A Functional and Putative Physiological Role of Calcitriol in Patched1/Smoothened Interaction.Identification of Novel Smoothened Ligands Using Structure-Based Docking.The Hedgehog pathway: role in cell differentiation, polarity and proliferation Cholesterolomics: An update Smoothened regulation in response to Hedgehog stimulation.Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma.Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols.Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.Sonidegib: mechanism of action, pharmacology, and clinical utility for advanced basal cell carcinomas.G-protein-coupled receptors, Hedgehog signaling and primary cilia.Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies.Canonical and non-canonical Hedgehog signalling and the control of metabolism.Regulation of the oncoprotein Smoothened by small molecules.Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction.The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis.Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy.Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.Bioorthogonal probes for imaging sterols in cells.Detergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs.A novel site comes into sight Lipid metabolism fattens up hedgehog signaling.

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P2860

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

http://www.wikidata.org/entity/Q27680483

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2013 nî lūn-bûn

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2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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Structure and function of the ...... vertebrate Hedgehog signaling

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Daniel M Whalen

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Douglas F Covey

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Kathiresan Krishnan

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Laurel K Mydock

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Rajat Rohatgi

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Zhonghua Zhao

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P2860

Structural basis for molecular recognition of folic acid by folate receptors

Evidence for allosteric interactions of antagonist binding to the smoothened receptor

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Small molecule modulation of Smoothened activity

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

Structural basis of Wnt recognition by Frizzled

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

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e01340

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scholarly article

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3138015

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10.7554/ELIFE.01340

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2

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Christian Siebold

Tomas Malinauskas

Sigrid Nachtergaele

Philip W Ingham

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2013-10-29T00:00:00Z

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258148405

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24171105

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3809587

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