Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
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Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugsStructural basis of Smoothened regulation by its extracellular domainsA Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia ElongationPrediction of G Protein-Coupled Receptors with SVM-Prot Features and Random ForestSmoothened goes molecular: new pieces in the hedgehog signaling puzzleTracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi.Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligandSmoothened Regulation: A Tale of Two Signals.Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling.The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.Functional Divergence in the Role of N-Linked Glycosylation in Smoothened SignalingSynthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail.A Functional and Putative Physiological Role of Calcitriol in Patched1/Smoothened Interaction.Identification of Novel Smoothened Ligands Using Structure-Based Docking.The Hedgehog pathway: role in cell differentiation, polarity and proliferationCholesterolomics: An updateSmoothened regulation in response to Hedgehog stimulation.Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma.Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols.Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.An essential role for Grk2 in Hedgehog signalling downstream of Smoothened.Sonidegib: mechanism of action, pharmacology, and clinical utility for advanced basal cell carcinomas.G-protein-coupled receptors, Hedgehog signaling and primary cilia.Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies.Canonical and non-canonical Hedgehog signalling and the control of metabolism.Regulation of the oncoprotein Smoothened by small molecules.Hedgehog signaling pathway: a novel model and molecular mechanisms of signal transduction.The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis.Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy.Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.Bioorthogonal probes for imaging sterols in cells.Detergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs.A novel site comes into sightLipid metabolism fattens up hedgehog signaling.
P2860
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P2860
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structure and function of the ...... vertebrate Hedgehog signaling
@ast
Structure and function of the ...... vertebrate Hedgehog signaling
@en
Structure and function of the ...... vertebrate Hedgehog signaling
@nl
type
label
Structure and function of the ...... vertebrate Hedgehog signaling
@ast
Structure and function of the ...... vertebrate Hedgehog signaling
@en
Structure and function of the ...... vertebrate Hedgehog signaling
@nl
prefLabel
Structure and function of the ...... vertebrate Hedgehog signaling
@ast
Structure and function of the ...... vertebrate Hedgehog signaling
@en
Structure and function of the ...... vertebrate Hedgehog signaling
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
Structure and function of the ...... vertebrate Hedgehog signaling
@en
P2093
Daniel M Whalen
Douglas F Covey
Kathiresan Krishnan
Laurel K Mydock
Rajat Rohatgi
Zhonghua Zhao
P2860
P304
P3181
P356
10.7554/ELIFE.01340
P407
P577
2013-10-29T00:00:00Z